KDM4B and H3-5

Data Source:
BioGRID (two hybrid)

		KDM4B	H3-5
Description		lysine demethylase 4B	H3.5 histone
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleosome Euchromatin Nucleus
	Molecular Function	Histone Demethylase Activity Histone Demethylase Activity (H3-K9 Specific) Metal Ion Binding Histone Demethylase Activity (H3-K36 Specific)	Protein Binding Nucleosomal DNA Binding Protein Heterodimerization Activity
	Biological Process	Chromatin Remodeling Histone H3-K9 Demethylation Histone H3-K36 Demethylation	Positive Regulation Of Cell Growth
Pathways		HDMs demethylate histones Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Periodontitis (CDC/AAP) ( 24024966) Pulse pressure ( 30578418) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653) Triglyceride levels ( 32203549) Urate levels ( 31578528)
Interacting Genes		2 interacting genes: H3-5 MED10	15 interacting genes: DAXX DNAJC9 FBLIM1 KAT6A KDM1A KDM4B NASP NSD3 PRMT5 PRMT6 PRMT7 SETMAR SMYD1 SMYD3 SUV39H1
Entrez ID		23030	440093
HPRD ID		11056	18443
Ensembl ID		ENSG00000127663	ENSG00000188375
Uniprot IDs		A0A0C4DFL8 F5GX28 O94953	Q6NXT2
PDB IDs		4LXL 4UC4	2PUY 3KV4 4Z5T 5BWN 5BWO 5F6K 5I3L 6OI3
Enriched GO Terms of Interacting Partners?
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