TPX2 and SIAH2

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		TPX2	SIAH2
Description		TPX2 microtubule nucleation factor	siah E3 ubiquitin protein ligase 2
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GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Spindle Cytosol Nuclear Microtubule Microtubule Cytoskeleton Axon Hillock Intercellular Bridge Mitotic Spindle	Nucleoplasm Cytoplasm Early Endosome Cytosol Neuron Projection Neuronal Cell Body Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Microtubule Binding Protein Kinase Binding Protein Kinase Activator Activity Importin-alpha Family Protein Binding	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity
	Biological Process	Mitotic Cell Cycle Apoptotic Process Microtubule Nucleation Negative Regulation Of Microtubule Depolymerization Regulation Of G2/M Transition Of Mitotic Cell Cycle Activation Of Protein Kinase Activity Cell Division Regulation Of Mitotic Spindle Organization Mitotic Spindle Assembly Regulation Of Signal Transduction By P53 Class Mediator	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Cell Cycle Small GTPase Mediated Signal Transduction Multicellular Organism Development Protein Deubiquitination Regulation Of Protein Ubiquitination Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Cellular Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Rhythmic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Netrin-activated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Regulation of TP53 Activity through Phosphorylation AURKA Activation by TPX2	Netrin-1 signaling Ub-specific processing proteases Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Immature fraction of reticulocytes ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Prudent dietary pattern ( 28644415)	BRCA1/2-negative high-risk breast cancer ( 30323354) Breast cancer ( 22951594 31757997)
Interacting Genes		8 interacting genes: AURKA CDK6 GOLGA2 HMMR NAP1L1 SIAH2 SUMO2 THAP11	43 interacting genes: AFF1 AKR1C3 ATN1 CACYBP CCBE1 CHEK2 DCC DYRK2 EEF1D EGLN3 HIPK2 HIPK3 MYD88 NRF1 OPRM1 PEG10 PEG3 PIAS2 PIAS3 PML POU2AF1 PSMD4 RBBP8 SETD2 SNCA SNCAIP SPRY2 STAT3 SYP TINF2 TP53BP2 TPX2 TRAF2 UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2L6 UBE2N UBE2V2 USP13 USP19 VAV1
Entrez ID		22974	6478
HPRD ID		05802	03737
Ensembl ID		ENSG00000088325	ENSG00000181788
Uniprot IDs		Q643R0 Q9ULW0	O43255
PDB IDs		1OL5 3E5A 3HA6 4C3P 5LXM 6BJC 6VPG 6VPH 6VPI 6VPJ 6VPL 6VPM 6XKA	5H9M
Enriched GO Terms of Interacting Partners?
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