TPX2 and THAP11

Data Source:
BioGRID (two hybrid)

		TPX2	THAP11
Description		TPX2 microtubule nucleation factor	THAP domain containing 11
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GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Spindle Cytosol Nuclear Microtubule Microtubule Cytoskeleton Axon Hillock Intercellular Bridge Mitotic Spindle	Chromatin Nucleoplasm Cytosol
	Molecular Function	Protein Binding Microtubule Binding Protein Kinase Binding Protein Kinase Activator Activity Importin-alpha Family Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding
	Biological Process	Mitotic Cell Cycle Apoptotic Process Microtubule Nucleation Negative Regulation Of Microtubule Depolymerization Regulation Of G2/M Transition Of Mitotic Cell Cycle Activation Of Protein Kinase Activity Cell Division Regulation Of Mitotic Spindle Organization Mitotic Spindle Assembly Regulation Of Signal Transduction By P53 Class Mediator	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II
Pathways		Regulation of TP53 Activity through Phosphorylation AURKA Activation by TPX2
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Immature fraction of reticulocytes ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Prudent dietary pattern ( 28644415)	Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252) Schizophrenia ( 25056061 29483656)
Interacting Genes		8 interacting genes: AURKA CDK6 GOLGA2 HMMR NAP1L1 SIAH2 SUMO2 THAP11	20 interacting genes: BBLN CASP3 CTBP1 ECT2 HCFC1 HDAC1 HDAC3 HEMGN L3MBTL2 LRRC45 MCPH1 NUTF2 PFDN6 PSMC5 SIN3A SLX1B SRSF11 THAP7 TPX2 VPS52
Entrez ID		22974	57215
HPRD ID		05802	11629
Ensembl ID		ENSG00000088325	ENSG00000168286
Uniprot IDs		Q643R0 Q9ULW0	Q96EK4
PDB IDs		1OL5 3E5A 3HA6 4C3P 5LXM 6BJC 6VPG 6VPH 6VPI 6VPJ 6VPL 6VPM 6XKA	2LAU 5AJS
Enriched GO Terms of Interacting Partners?
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