RAB18 and PPP2R1A

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		RAB18	PPP2R1A
Description		RAB18, member RAS oncogene family	protein phosphatase 2 scaffold subunit Aalpha
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Cytosol Plasma Membrane Endomembrane System Apical Plasma Membrane Secretory Granule Membrane Endoplasmic Reticulum Tubular Network	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Cytoplasm Mitochondrion Cytosol Protein Serine/threonine Phosphatase Complex Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Dendrite Extracellular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity Protein Heterodimerization Activity Protein Antigen Binding
	Biological Process	Eye Development Intracellular Protein Transport Small GTPase Mediated Signal Transduction Brain Development Viral Process Lipid Droplet Organization Neutrophil Degranulation Endoplasmic Reticulum Tubular Network Organization	G2/M Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Inactivation Of MAPK Activity Regulation Of DNA Replication Regulation Of Transcription, DNA-templated Protein Dephosphorylation Ceramide Metabolic Process Apoptotic Process Chromosome Segregation Mitotic Nuclear Envelope Reassembly RNA Splicing Response To Organic Substance Regulation Of G2/M Transition Of Mitotic Cell Cycle Second-messenger-mediated Signaling Regulation Of Wnt Signaling Pathway Regulation Of Cell Adhesion Negative Regulation Of Cell Growth Regulation Of Growth Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Cell Differentiation Protein-containing Complex Assembly Ciliary Basal Body-plasma Membrane Docking
Pathways		Neutrophil degranulation COPI-independent Golgi-to-ER retrograde traffic RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Integration of energy metabolism PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Initiation of Nuclear Envelope (NE) Reformation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition AURKA Activation by TPX2 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs			2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases		Warburg micro syndrome
GWAS		Benign childhood epilepsy with centro-temporal spikes ( 32580138) Childhood ear infection ( 27182965 28928442) Diisocyanate-induced asthma ( 25918132) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Hip circumference adjusted for BMI ( 28552196) Refractive error ( 32231278)
Interacting Genes		10 interacting genes: AQP6 CHM ELOVL4 ERRFI1 FAM107A PDE6D PPP2R1A PPP2R1B TAX1BP1 TOM1L1	57 interacting genes: AIMP2 AKT1 AMOTL2 ARIH2 CARD11 CARHSP1 CDC42 CDK1 CSDC2 CSNK2B DAPK1 DELEC1 DUX4 EEF2 ESR1 FBXO43 GNA12 GOLGA6A GOLGA8F GRIN1 GRIN2D HSF2 HSPD1 IPO9 LINC01554 MAP3K7 MAPK6 MCM3 PARK7 PLAAT3 PPP2CA PPP2R2A PPP2R3B PPP2R5A PPP2R5B PPP2R5D PPP4C PPP5C PRDX1 PRDX2 PTPA RAB11A RAB18 RAB7A RAP1A RORC SGO1 SGO2 SLC6A2 SMAD2 SMAD3 STRN STRN3 SUMO2 TAB1 TRADD ZFYVE9
Entrez ID		22931	5518
HPRD ID		03731	16184
Ensembl ID		ENSG00000099246	ENSG00000105568
Uniprot IDs		A0A087X163 B7Z4P9 B7Z5V3 Q9NP72	A8K7B7 P30153
PDB IDs		1X3S	1B3U 2IE3 2IE4 2NPP 2NYL 2NYM 2PKG 3C5W 3DW8 3K7V 3K7W 4I5L 4I5N 4LAC 5W0W 6IUR 6NTS
Enriched GO Terms of Interacting Partners?
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