FKBP2 and MAP3K11

Data Source:
BioGRID (genetic interference)

		FKBP2	MAP3K11
Description		FKBP prolyl isomerase 2	mitogen-activated protein kinase kinase kinase 11
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane	Cytoplasm Centrosome Microtubule Membrane
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Protein Peptidyl-prolyl Isomerization	Activation Of MAPK Activity Protein Phosphorylation Microtubule-based Process JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Cell Cycle G1/S Phase Transition Positive Regulation Of JNK Cascade Protein Autophosphorylation
Pathways			RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs			Fostamatinib
Diseases
GWAS		Crohn's disease ( 28067908) Fruit consumption ( 32066663)	Acne (severe) ( 24927181 30542056) Coronary artery disease ( 29212778) Eosinophil counts ( 27863252) Estimated glomerular filtration rate ( 31015462) Gout ( 25646370) Mean platelet volume ( 27863252) Refractive error ( 32231278) Serum uric acid levels ( 32514006) Sum eosinophil basophil counts ( 27863252) Type 2 diabetes ( 28566273 30297969)
Interacting Genes		14 interacting genes: ARFGEF1 BAG6 BARD1 C1QC EPB41 EPB41L2 MAPK3 RAB3C RAB6A RAP2A UBQLN1 UBQLN2 UBQLN4 VAMP2	27 interacting genes: AKT1 APP CDC42 CHUK CLEC4G COPS5 EPS8 IKBKB KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAP2K7 MAP3K12 MAP3K21 MAP4K1 MAP4K2 MAPK8IP1 MAPK8IP2 MAPK8IP3 PIN1 RAC1 RHOG SH3RF1 STUB1 TRAF6
Entrez ID		2286	4296
HPRD ID		01742	02502
Ensembl ID		ENSG00000173486	ENSG00000173327
Uniprot IDs		P26885 Q53XJ5	A0A024R5E6 Q16584
PDB IDs		2PBC 4NNR	5K26 5K28 6AQB 6CQ7
Enriched GO Terms of Interacting Partners?
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