CLCA4 and MCFD2

Data Source:
BioGRID (two hybrid)

		CLCA4	MCFD2
Description		chloride channel accessory 4	multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane	Golgi Membrane Endoplasmic Reticulum Membrane ER To Golgi Transport Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Intracellular Calcium Activated Chloride Channel Activity Chloride Channel Activity Metallopeptidase Activity Metal Ion Binding	Calcium Ion Binding Protein Binding
	Biological Process	Proteolysis Ion Transmembrane Transport Chloride Transmembrane Transport	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Protein N-linked Glycosylation Via Asparagine COPII Vesicle Coating
Pathways		Stimuli-sensing channels	COPII-mediated vesicle transport Cargo concentration in the ER Transport to the Golgi and subsequent modification
Drugs			Antihemophilic factor, human recombinant Lonoctocog alfa Moroctocog alfa
Diseases			Combined deficiency of factors V and VIII (F5F8D)
GWAS			Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Mean reticulocyte volume ( 32888494) Response to statin therapy ( 20339536)
Interacting Genes		23 interacting genes: AQP2 BDKRB2 ELOVL4 ERGIC3 FAM209A FCER1G FKBP7 GPR42 LMNA MCFD2 MGST3 PANX1 RETREG3 SCN3B SLC22A23 SLC35E2A SLC39A2 SLC39A7 SPN THAP4 TMEM154 TMEM179B TMEM51	11 interacting genes: APP CLCA4 CMTM5 F8 IL1RL1 LMAN1 P2RY6 PNLIPRP1 SCD SLC35A1 SYS1
Entrez ID		22802	90411
HPRD ID		16719	09693
Ensembl ID		ENSG00000016602	ENSG00000180398
Uniprot IDs		Q14CN2	B4DF17 Q8NI22
PDB IDs			2VRG 3A4U 3LCP 3WHT 3WHU 3WNX 4YGB 4YGC 4YGD 4YGE
Enriched GO Terms of Interacting Partners?
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