FGF13 and SCN8A

Data Source:
HPRD (two hybrid, in vivo)

		FGF13	SCN8A
Description		fibroblast growth factor 13	sodium voltage-gated channel alpha subunit 8
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleolus Cytoplasm Cytosol Microtubule Plasma Membrane Intercalated Disc Lateral Plasma Membrane Filopodium Axon Dendrite Growth Cone Neuron Projection	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Membrane Z Disc Cell Junction Axon Cytoplasmic Vesicle Node Of Ranvier Axon Initial Segment
	Molecular Function	Protein Binding Microtubule Binding Growth Factor Activity Sodium Channel Regulator Activity Protein Kinase Activator Activity Ion Channel Binding Beta-tubulin Binding	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Protein Binding ATP Binding
	Biological Process	MAPK Cascade Neuron Migration Sodium Ion Transport Negative Regulation Of Microtubule Depolymerization Signal Transduction Cell-cell Signaling Nervous System Development Learning Memory Hippocampus Development Cerebral Cortex Cell Migration Activation Of Protein Kinase Activity Establishment Of Neuroblast Polarity Microtubule Polymerization Negative Regulation Of Collateral Sprouting Protein Localization To Plasma Membrane Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Inhibitory Synapse Assembly Regulation Of Voltage-gated Sodium Channel Activity	Sodium Ion Transport Nervous System Development Peripheral Nervous System Development Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Membrane Depolarization During Action Potential
Pathways		Phase 0 - rapid depolarisation	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs			Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Cocaine Promethazine Tetrodotoxin Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases
GWAS		Breast cancer in BRCA2 mutation carriers ( 23544012) Response to taxane treatment (placlitaxel) ( 23006423)	Alcohol consumption ( 31358974) Alcohol use disorder (consumption score) ( 30940813) Chronotype ( 30696823) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Response to antidepressants and depression ( 27622933)
Interacting Genes		7 interacting genes: APP FBXO7 MAPK8IP2 PLEKHF2 PRNP PSEN1 SCN8A	4 interacting genes: FGF13 FGF14 GNAO1 MAPK14
Entrez ID		2258	6334
HPRD ID		02090	09006
Ensembl ID		ENSG00000129682	ENSG00000196876
Uniprot IDs		A8K1P5 Q92913	Q6B4S4 Q9UQD0
PDB IDs		3HBW 4DCK 4JPZ
Enriched GO Terms of Interacting Partners?
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