MAPK15 and CLIC3

Data Source:
HPRD (in vivo)

		MAPK15	CLIC3
Description		mitogen-activated protein kinase 15	chloride intracellular channel 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Autophagosome Golgi Apparatus Centriole Cell-cell Junction Bicellular Tight Junction Axoneme Cytoplasmic Vesicle Ciliary Basal Body Meiotic Spindle	Nucleus Cytoplasm Nuclear Body Chloride Channel Complex Extracellular Exosome
	Molecular Function	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity SH3 Domain Binding	Voltage-gated Ion Channel Activity Chloride Channel Activity Protein Binding
	Biological Process	MAPK Cascade Regulation Of COPII Vesicle Coating Cellular Response To DNA Damage Stimulus Endoplasmic Reticulum Organization Positive Regulation Of Cell Population Proliferation Regulation Of Autophagy Negative Regulation Of Cell Migration Positive Regulation Of Telomere Maintenance Via Telomerase Intracellular Signal Transduction Protein Autophosphorylation Positive Regulation Of Telomerase Activity Dopamine Uptake Regulation Of Cilium Assembly Positive Regulation Of Telomere Capping Protein Localization To Ciliary Transition Zone Positive Regulation Of Metaphase/anaphase Transition Of Meiosis I Positive Regulation Of Spindle Assembly	Glutathione Metabolic Process Chloride Transport Signal Transduction Regulation Of Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways
Drugs		Acetylsalicylic acid Minocycline Fostamatinib
Diseases
GWAS		Obesity-related traits ( 23251661)
Interacting Genes		8 interacting genes: CLIC3 CSK GABARAP GABARAPL1 MBP NR3C1 SRC TGFB1I1	35 interacting genes: AGR2 ALX1 ANKRD23 ANKRD55 APP C7orf31 C9orf24 DDIT4L DNM1 EFHC2 FAM166B GLYR1 INCA1 KATNBL1 KRT85 KRTAP13-3 LELP1 MAPK15 MBD3L1 MECOM MIA3 MSX2 POT1 PROSER2 SCML4 STMN3 TBC1D3 TBC1D3C TBC1D3K TEPSIN TLE5 VPS4A ZBTB42 ZC2HC1C ZNF620
Entrez ID		225689	9022
HPRD ID		16867	05941
Ensembl ID		ENSG00000181085	ENSG00000169583
Uniprot IDs		Q8TD08	O95833 Q6FGP1
PDB IDs			3FY7 3KJY
Enriched GO Terms of Interacting Partners?
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