Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
FGF2 and RPL6
Data Source:
HPRD
(two hybrid, in vitro)
FGF2
RPL6
Description
fibroblast growth factor 2
ribosomal protein L6
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Nucleus
Rough Endoplasmic Reticulum
Cytosol
Focal Adhesion
Postsynaptic Density
Membrane
Cytosolic Large Ribosomal Subunit
Cytoplasmic Ribonucleoprotein Granule
Polysomal Ribosome
Molecular Function
Fibroblast Growth Factor Receptor Binding
Cytokine Activity
Integrin Binding
Protein Binding
Growth Factor Activity
Heparin Binding
Chemokine Binding
Nuclear Receptor Coactivator Activity
Chemoattractant Activity
Identical Protein Binding
Receptor-receptor Interaction
DNA Binding
RNA Binding
Structural Constituent Of Ribosome
Protein Binding
Cadherin Binding
Biological Process
MAPK Cascade
Activation Of MAPK Activity
Branching Involved In Ureteric Bud Morphogenesis
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Cell Migration Involved In Sprouting Angiogenesis
Phosphatidylinositol Biosynthetic Process
Chemotaxis
Signal Transduction
Ras Protein Signal Transduction
Nervous System Development
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Animal Organ Morphogenesis
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Fibroblast Migration
Positive Regulation Of Phospholipase C Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation
Cytokine-mediated Signaling Pathway
Cell Differentiation
Extracellular Matrix Organization
Hyaluronan Catabolic Process
Lung Development
Regulation Of Cell Migration
Inositol Phosphate Biosynthetic Process
Somatic Stem Cell Population Maintenance
Paracrine Signaling
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Wound Healing
Positive Regulation Of Cell Fate Specification
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Regulation Of Angiogenesis
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Embryonic Morphogenesis
Positive Regulation Of Epithelial Cell Proliferation
Positive Chemotaxis
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Cell Division
Positive Regulation Of Protein Kinase B Signaling
Positive Regulation Of Cardiac Muscle Cell Proliferation
Negative Regulation Of Cell Death
Chondroblast Differentiation
Negative Regulation Of Wound Healing
Positive Regulation Of ERK1 And ERK2 Cascade
Stem Cell Proliferation
Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Lens Fiber Cell Differentiation
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Positive Regulation Of Sprouting Angiogenesis
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Epithelial Tube Formation
Positive Regulation Of Vascular Endothelial Cell Proliferation
Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Positive Regulation Of DNA Biosynthetic Process
Positive Regulation Of Endothelial Cell Chemotaxis
Ribosomal Large Subunit Assembly
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Cytoplasmic Translation
Regulation Of Transcription, DNA-templated
Translation
Translational Initiation
SRP-dependent Cotranslational Protein Targeting To Membrane
Viral Transcription
Pathways
PI3K Cascade
PIP3 activates AKT signaling
Signaling by activated point mutants of FGFR1
Signaling by activated point mutants of FGFR3
FGFR4 ligand binding and activation
FGFR1b ligand binding and activation
FGFR3c ligand binding and activation
FGFR1c ligand binding and activation
FGFR2c ligand binding and activation
FGFR2b ligand binding and activation
FGFR3 mutant receptor activation
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Syndecan interactions
Non-integrin membrane-ECM interactions
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Signaling by FGFR2 in disease
Signaling by FGFR1 in disease
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signaling by FGFR2 IIIa TM
Signaling by FGFR3 point mutants in cancer
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Response of EIF2AK4 (GCN2) to amino acid deficiency
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Sucralfate
Pentosan polysulfate
Sirolimus
Heparin
1,4-Dideoxy-O2-Sulfo-Glucuronic Acid
N,O6-Disulfo-Glucosamine
1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid
ABT-510
Diseases
GWAS
Acne (severe) (
30542056
)
Blood protein levels (
28240269
)
Body mass index (
25673413
)
Irritable bowel syndrome (
24797007
)
Mosquito bite size (
28199695
)
Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) (
28443625
)
Waist-to-hip ratio adjusted for body mass index (
25673412
)
Blond vs. brown/black hair color (
30531825
)
Blood pressure (
21572416
)
Body mass index (
26426971
)
Coffee consumption (
29367735
)
Diastolic blood pressure (
26390057
)
Esophageal cancer (
21642993
)
Systolic blood pressure (
26390057
)
Interacting Genes
31 interacting genes:
API5
CASP1
CD44
CEP57
CRYAB
CSNK2A1
CSNK2A2
CSNK2B
CXCL13
FGFBP1
FGFR1
FGFR2
FGFR3
FGFR4
FGFRL1
GPC3
GPC4
HSPG2
NRP1
PF4
PRMT1
PTX3
RPL6
RPS19
RPS6KA3
SDC1
SDC2
SDC3
SNTG1
THBS1
VTN
16 interacting genes:
CSNK2A1
DUX4
EIF6
FBXO7
FGF2
H2AC4
IL7R
IVNS1ABP
LINC01554
MAP3K14
MT-ND1
NFKB2
NPAS2
RPL29
SEL1L
STAU1
Entrez ID
2247
6128
HPRD ID
00622
04745
Ensembl ID
ENSG00000138685
ENSG00000089009
Uniprot IDs
P09038
A0A024RBK3
Q02878
Q8TBK5
PDB IDs
1BAS
1BFB
1BFC
1BFF
1BFG
1BLA
1BLD
1CVS
1EV2
1FGA
1FQ9
1II4
1IIL
2BFH
2FGF
2M49
4FGF
4OEE
4OEF
4OEG
5X1O
6L4O
4UG0
4V6X
5AJ0
5LKS
5T2C
6EK0
6IP5
6IP6
6IP8
6LQM
6LSR
6LSS
6LU8
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6W6L
6XA1
6Y0G
6Y2L
6Y57
6Y6X
6Z6L
6Z6M
6Z6N
6ZM7
6ZME
6ZMI
6ZMO
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?