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FGF2 and FGFR3
Data Source:
HPRD
(in vivo)
FGF2
FGFR3
Description
fibroblast growth factor 2
fibroblast growth factor receptor 3
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Extracellular Region
Nucleus
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Cell Surface
Transport Vesicle
Receptor Complex
Molecular Function
Fibroblast Growth Factor Receptor Binding
Cytokine Activity
Integrin Binding
Protein Binding
Growth Factor Activity
Heparin Binding
Chemokine Binding
Nuclear Receptor Coactivator Activity
Chemoattractant Activity
Identical Protein Binding
Receptor-receptor Interaction
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Fibroblast Growth Factor-activated Receptor Activity
Protein Binding
ATP Binding
Fibroblast Growth Factor Binding
Identical Protein Binding
Biological Process
MAPK Cascade
Activation Of MAPK Activity
Branching Involved In Ureteric Bud Morphogenesis
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Cell Migration Involved In Sprouting Angiogenesis
Phosphatidylinositol Biosynthetic Process
Chemotaxis
Signal Transduction
Ras Protein Signal Transduction
Nervous System Development
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Animal Organ Morphogenesis
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Fibroblast Migration
Positive Regulation Of Phospholipase C Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation
Cytokine-mediated Signaling Pathway
Cell Differentiation
Extracellular Matrix Organization
Hyaluronan Catabolic Process
Lung Development
Regulation Of Cell Migration
Inositol Phosphate Biosynthetic Process
Somatic Stem Cell Population Maintenance
Paracrine Signaling
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Wound Healing
Positive Regulation Of Cell Fate Specification
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Regulation Of Angiogenesis
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Embryonic Morphogenesis
Positive Regulation Of Epithelial Cell Proliferation
Positive Chemotaxis
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Cell Division
Positive Regulation Of Protein Kinase B Signaling
Positive Regulation Of Cardiac Muscle Cell Proliferation
Negative Regulation Of Cell Death
Chondroblast Differentiation
Negative Regulation Of Wound Healing
Positive Regulation Of ERK1 And ERK2 Cascade
Stem Cell Proliferation
Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Lens Fiber Cell Differentiation
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Positive Regulation Of Sprouting Angiogenesis
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Epithelial Tube Formation
Positive Regulation Of Vascular Endothelial Cell Proliferation
Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Positive Regulation Of DNA Biosynthetic Process
Positive Regulation Of Endothelial Cell Chemotaxis
MAPK Cascade
Skeletal System Development
Endochondral Ossification
Chondrocyte Differentiation
Endochondral Bone Growth
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cell-cell Signaling
Multicellular Organism Development
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Phospholipase Activity
Peptidyl-tyrosine Phosphorylation
Bone Mineralization
Positive Regulation Of Kinase Activity
Chondrocyte Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of MAPK Cascade
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Protein Autophosphorylation
Negative Regulation Of Developmental Growth
Positive Regulation Of Protein Kinase B Signaling
Bone Morphogenesis
Positive Regulation Of ERK1 And ERK2 Cascade
Bone Maturation
Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway
Pathways
PI3K Cascade
PIP3 activates AKT signaling
Signaling by activated point mutants of FGFR1
Signaling by activated point mutants of FGFR3
FGFR4 ligand binding and activation
FGFR1b ligand binding and activation
FGFR3c ligand binding and activation
FGFR1c ligand binding and activation
FGFR2c ligand binding and activation
FGFR2b ligand binding and activation
FGFR3 mutant receptor activation
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Syndecan interactions
Non-integrin membrane-ECM interactions
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Signaling by FGFR2 in disease
Signaling by FGFR1 in disease
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signaling by FGFR2 IIIa TM
Signaling by FGFR3 point mutants in cancer
Signaling by activated point mutants of FGFR3
FGFR3 mutant receptor activation
t(4;14) translocations of FGFR3
Signaling by FGFR3 fusions in cancer
Signaling by FGFR3 point mutants in cancer
Drugs
Sucralfate
Pentosan polysulfate
Sirolimus
Heparin
1,4-Dideoxy-O2-Sulfo-Glucuronic Acid
N,O6-Disulfo-Glucosamine
1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid
ABT-510
XL999
Pazopanib
Ponatinib
Lenvatinib
Nintedanib
Fostamatinib
Erdafitinib
Pemigatinib
Selpercatinib
Diseases
Bladder cancer
Multiple myeloma
Lacrimo-auriculo-dento-digital syndrome (LADD); Levy-Hollister syndrome
Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
FGFR3-related short limb skeletal dysplasias, including: Achondroplasia; Hypochondroplasia; Thanatophoric dysplasia, type 1; Thanatophoric dysplasia, type 2; Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN)
CATSHL syndrome
GWAS
Acne (severe) (
30542056
)
Blood protein levels (
28240269
)
Body mass index (
25673413
)
Irritable bowel syndrome (
24797007
)
Mosquito bite size (
28199695
)
Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) (
28443625
)
Waist-to-hip ratio adjusted for body mass index (
25673412
)
Bladder cancer (
24163127
20972438
)
Blood protein levels (
30072576
)
Metabolite levels (
23823483
)
Urinary bladder cancer (
20348956
)
Interacting Genes
31 interacting genes:
API5
CASP1
CD44
CEP57
CRYAB
CSNK2A1
CSNK2A2
CSNK2B
CXCL13
FGFBP1
FGFR1
FGFR2
FGFR3
FGFR4
FGFRL1
GPC3
GPC4
HSPG2
NRP1
PF4
PRMT1
PTX3
RPL6
RPS19
RPS6KA3
SDC1
SDC2
SDC3
SNTG1
THBS1
VTN
43 interacting genes:
ANOS1
ARAP1
ATF3
BORA
C6orf47
CCDC17
CEP126
CHGB
CTSK
EPHA4
ERBB2
FGF1
FGF17
FGF18
FGF2
FGF23
FGF3
FGF4
FGF5
FGF6
FGF7
FGF8
FGF9
GPSM3
GRB2
GTF3C1
HBZ
HNRNPL
KRT8
NDUFS6
NECTIN1
POLA2
PTK2B
RADIL
RNF130
RPL8
RPS6KA3
SH2B1
SLC25A6
SMG7
SRPK2
STAT1
STAT3
Entrez ID
2247
2261
HPRD ID
00622
00624
Ensembl ID
ENSG00000138685
ENSG00000068078
Uniprot IDs
P09038
P22607
Q0IJ44
PDB IDs
1BAS
1BFB
1BFC
1BFF
1BFG
1BLA
1BLD
1CVS
1EV2
1FGA
1FQ9
1II4
1IIL
2BFH
2FGF
2M49
4FGF
4OEE
4OEF
4OEG
5X1O
6L4O
1RY7
2LZL
4K33
6LVM
6PNX
Enriched GO Terms of Interacting Partners
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