FGA and TMEM43

Data Source:
BioGRID (two hybrid)

		FGA	TMEM43
Description		fibrinogen alpha chain	transmembrane protein 43
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Cell Cortex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Platelet Alpha Granule Lumen Synapse Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle Extracellular Vesicle	Integral Component Of Nuclear Inner Membrane Endoplasmic Reticulum Golgi Apparatus
	Molecular Function	Signaling Receptor Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding	Protein Binding Identical Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway Adaptive Immune Response Platelet Degranulation Cell-matrix Adhesion Blood Coagulation Extracellular Matrix Organization Plasminogen Activation Positive Regulation Of Heterotypic Cell-cell Adhesion Cellular Protein-containing Complex Assembly Fibrinolysis Induction Of Bacterial Agglutination Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Protein-containing Complex Assembly Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Blood Coagulation, Common Pathway Blood Coagulation, Fibrin Clot Formation Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process	Nuclear Membrane Organization
Pathways		Platelet degranulation Common Pathway of Fibrin Clot Formation Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MAP2K and MAPK activation Regulation of TLR by endogenous ligand Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Post-translational protein phosphorylation Signaling downstream of RAS mutants Signaling by RAF1 mutants Amyloid fiber formation
Drugs		Alteplase Reteplase Anistreplase Tenecteplase Sucralfate Zinc Alfimeprase Ancrod EP-2104R Lanoteplase Thrombin Prothrombin Human thrombin Thrombin alfa Anti-inhibitor coagulant complex Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Afibrinogenemia; Dysfibrinogenemia Inherited thrombophilia Familial amyloidosis
GWAS		D-dimer levels ( 21502573) Fibrinogen ( 20031577 21757653) Ischemic stroke ( 29531354) Stroke ( 29531354) Venous thromboembolism ( 21980494)	Heel bone mineral density ( 30598549)
Interacting Genes		27 interacting genes: AGTRAP APP CDH5 EXOC5 F13A1 F2 FGB FGG HRG ITGA2B ITGB3 MEOX2 NID1 PLAT PRRC2A SERPINA5 SERPINF2 SH3BP1 STX1B STX2 SYCE1L TFIP11 THBS1 TMEM43 TPM1 TPM3 UBC	16 interacting genes: APOA5 ARL13B CARD10 CISD2 FAM209A FDFT1 FGA FKBP8 GRAMD2B LMNA PCYT1B SCGB1A1 SIAH1 SYNDIG1 USP25 ZCCHC12
Entrez ID		2243	79188
HPRD ID		00619	15541
Ensembl ID		ENSG00000171560	ENSG00000170876
Uniprot IDs		P02671	A0A024R2F9 Q9BTV4
PDB IDs		1BBR 1DM4 1FPH 1FZA 1FZB 1FZC 1FZD 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 1YCP 2A45 2FFD 2H43 2HLO 2HOD 2HPC 2OYH 2OYI 2Q9I 2XNX 2XNY 2Z4E 3AT0 3BVH 3E1I 3GHG 3H32 3HUS 4F27 5CFA
Enriched GO Terms of Interacting Partners?
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