FGA and ITGA2B

Data Source:
HPRD (in vitro)

		FGA	ITGA2B
Description		fibrinogen alpha chain	integrin subunit alpha 2b
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GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Cell Cortex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Platelet Alpha Granule Lumen Synapse Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle Extracellular Vesicle	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Membrane Extracellular Exosome Blood Microparticle
	Molecular Function	Signaling Receptor Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding	Protein Binding Identical Protein Binding Metal Ion Binding Extracellular Matrix Binding Fibrinogen Binding
	Biological Process	Toll-like Receptor Signaling Pathway Adaptive Immune Response Platelet Degranulation Cell-matrix Adhesion Blood Coagulation Extracellular Matrix Organization Plasminogen Activation Positive Regulation Of Heterotypic Cell-cell Adhesion Cellular Protein-containing Complex Assembly Fibrinolysis Induction Of Bacterial Agglutination Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Protein-containing Complex Assembly Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Blood Coagulation, Common Pathway Blood Coagulation, Fibrin Clot Formation Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process	Platelet Degranulation Positive Regulation Of Leukocyte Migration Cell-matrix Adhesion Integrin-mediated Signaling Pathway Extracellular Matrix Organization Regulation Of Megakaryocyte Differentiation Platelet Aggregation
Pathways		Platelet degranulation Common Pathway of Fibrin Clot Formation Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MAP2K and MAPK activation Regulation of TLR by endogenous ligand Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Post-translational protein phosphorylation Signaling downstream of RAS mutants Signaling by RAF1 mutants Amyloid fiber formation	Platelet degranulation Integrin cell surface interactions ECM proteoglycans Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Signal transduction by L1 MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs		Alteplase Reteplase Anistreplase Tenecteplase Sucralfate Zinc Alfimeprase Ancrod EP-2104R Lanoteplase Thrombin Prothrombin Human thrombin Thrombin alfa Anti-inhibitor coagulant complex Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Abciximab Tirofiban Lefradafiban Fradafiban
Diseases		Afibrinogenemia; Dysfibrinogenemia Inherited thrombophilia Familial amyloidosis	Glanzmann thrombasthenia
GWAS		D-dimer levels ( 21502573) Fibrinogen ( 20031577 21757653) Ischemic stroke ( 29531354) Stroke ( 29531354) Venous thromboembolism ( 21980494)	Brain morphology (MOSTest) ( 32665545) Mean platelet volume ( 32888494 27863252) Platelet count ( 22139419 32888494 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 32888494)
Interacting Genes		27 interacting genes: AGTRAP APP CDH5 EXOC5 F13A1 F2 FGB FGG HRG ITGA2B ITGB3 MEOX2 NID1 PLAT PRRC2A SERPINA5 SERPINF2 SH3BP1 STX1B STX2 SYCE1L TFIP11 THBS1 TMEM43 TPM1 TPM3 UBC	20 interacting genes: APP AUP1 CALR CAMK2A CD36 CIB1 CLNS1A COL1A2 COL2A1 F2 FGA FGG FN1 GRB2 ITGB3 PLA2G4A PRKACA SHARPIN TLN1 VWF
Entrez ID		2243	3674
HPRD ID		00619	06377
Ensembl ID		ENSG00000171560	ENSG00000005961
Uniprot IDs		P02671	P08514
PDB IDs		1BBR 1DM4 1FPH 1FZA 1FZB 1FZC 1FZD 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 1YCP 2A45 2FFD 2H43 2HLO 2HOD 2HPC 2OYH 2OYI 2Q9I 2XNX 2XNY 2Z4E 3AT0 3BVH 3E1I 3GHG 3H32 3HUS 4F27 5CFA	1DPK 1DPQ 1JX5 1KUP 1KUZ 1M8O 1RN0 1S4W 1TYE 1UV9 2K1A 2K9J 2KNC 2MTP 2N9Y 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2 4CAK 4Z7N 4Z7O 4Z7Q 5HDB 6V4P
Enriched GO Terms of Interacting Partners?
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