FGD2 and RPRM

Data Source:
BioGRID (two hybrid)

		FGD2	RPRM
Description		FYVE, RhoGEF and PH domain containing 2	reprimo, TP53 dependent G2 arrest mediator homolog
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Lamellipodium Early Endosome Membrane Ruffle Membrane	Cytoplasm Integral Component Of Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding Metal Ion Binding Phosphatidylinositol Phosphate Binding	Protein Binding
	Biological Process	Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Shape Actin Cytoskeleton Organization Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of JUN Kinase Activity Filopodium Assembly Regulation Of Small GTPase Mediated Signal Transduction	Cell Cycle Arrest Regulation Of Mitotic Cell Cycle
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Medication use (thyroid preparations) ( 31015401) Rosacea symptom severity ( 29771307)	Anti-saccade response ( 29064472) Blood trace element (Zn levels) ( 23720494) Heel bone mineral density ( 30598549) Lung cancer ( 28604730)
Interacting Genes		5 interacting genes: CDC42 KLHL12 PLEKHG4 RPRM TMEM239	79 interacting genes: ADGRG3 AMIGO1 AQP6 ARFIP1 ASGR2 BNIP3 BSCL2 BTNL9 C16orf54 CD33 CD53 CD69 CLDN5 CLDN7 CLDN9 CLEC17A CLEC2D COQ8A CREB3 CXorf66 EHHADH EMP1 FAM209A FAM210B FATE1 FBXL19 FCGR1A FFAR2 FGD2 FKBP7 FNDC9 GAD2 GJA5 GJB3 GJB5 GNG13 GPR37L1 GPR42 HHLA2 HIP1 HSD17B13 KCNJ6 LAPTM5 LHFPL5 LMNA LPAR6 MPP1 MS4A4A MTIF3 OPRD1 OPRM1 PBX3 PDZK1IP1 PLEKHF2 PNKP SCAND1 SDCBP SENP2 SLC18A1 SLC38A1 SMIM3 SNX11 SNX12 SNX3 SPACA1 SPCS1 STOM SUSD3 SYT16 TM4SF18 TMEM106C TMEM237 TMEM79 TMEM80 TMEM86B TSPO2 TTPA WDFY2 ZDHHC22
Entrez ID		221472	56475
HPRD ID		05478	18002
Ensembl ID		ENSG00000146192	ENSG00000177519
Uniprot IDs		Q7Z6J4	Q9NS64
PDB IDs
Enriched GO Terms of Interacting Partners?
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