SPATS1 and SPG7

Data Source:
BioGRID (two hybrid)

		SPATS1	SPG7
Description		spermatogenesis associated serine rich 1	SPG7 matrix AAA peptidase subunit, paraplegin
Image		No pdb structure
GO Annotations	Cellular Component		Mitochondrion Mitochondrial Inner Membrane Mitochondrial Permeability Transition Pore Complex
	Molecular Function	Protein Binding	ATP-dependent Peptidase Activity Metalloendopeptidase Activity Protein Binding ATP Binding Peptidase Activity Zinc Ion Binding Unfolded Protein Binding
	Biological Process		Proteolysis Mitochondrial Calcium Ion Transmembrane Transport Nervous System Development Mitochondrial Fusion Mitochondrial Protein Processing Cristae Formation Regulation Of Mitochondrial Membrane Permeability Protein-containing Complex Assembly Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death
Pathways			Processing of SMDT1
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Itch intensity from mosquito bite adjusted by bite size ( 28199695)	Hair morphology traits ( 30166351) Heel bone mineral density ( 30598549) Type 2 diabetes ( 30297969) White coat effect (clinic systolic blood pressure minus ambulatory systolic blood pressure) ( 31044621)
Interacting Genes		9 interacting genes: CFLAR CTNNA3 GPHN KCTD9 MISP SPG7 TRIM55 TRIM63 ZIC1	29 interacting genes: BDKRB2 CCNDBP1 CYSRT1 HNRNPK HSF2BP KHDRBS2 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP4-12 KRTAP5-9 LRIF1 LZTS2 MAPK6 MDFI MTUS2 NBPF19 NOTCH2NLA PLSCR1 PNMA1 PSME3 PSTPIP1 RALY RBPMS SASH1 SPATS1 STAMBP TRIM28
Entrez ID		221409	6687
HPRD ID		10248	04149
Ensembl ID		ENSG00000249481	ENSG00000197912
Uniprot IDs		Q496A3	A0A2R8Y632 Q9UQ90
PDB IDs			2QZ4
Enriched GO Terms of Interacting Partners?
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