FCGR2A and FCER1A

Data Source:
BioGRID (biochemical)

		FCGR2A	FCER1A
Description		Fc fragment of IgG receptor IIa	Fc fragment of IgE receptor Ia
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GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Secretory Granule Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding IgG Binding	Transmembrane Signaling Receptor Activity Protein Binding IgE Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Neutrophil Degranulation Regulation Of Immune Response	Cell Surface Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Immune Response
Pathways		FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Neutrophil degranulation FCGR3A-mediated IL10 synthesis	Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation
Drugs		Cetuximab Etanercept Human immunoglobulin G Abciximab Alemtuzumab Daclizumab Bevacizumab Catumaxomab Sarilumab	Omalizumab Benzylpenicilloyl polylysine TNX-901
Diseases		Systemic lupus erythematosus
GWAS		Ankylosing spondylitis ( 23749187) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576 29875488 28240269) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Hematocrit ( 27863252) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28067908 23128233) Kawasaki disease ( 28886140 22081228) Lipid metabolism phenotypes ( 22286219) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966 24871463 26663301 26502338 28714469) Takayasu arteritis ( 23830517) Ulcerative colitis ( 19915573 28067908 20228799 21297633)	C-reactive protein ( 22939635) IgE levels ( 18846228 22075330) Obesity-related traits ( 23251661) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Select biomarker traits ( 17903293) White blood cell count ( 27863252)
Interacting Genes		26 interacting genes: ADAM33 AGPAT4 BLK CDIPT CMTM5 CRP CRYAB CSGALNACT2 CXCL9 FXYD3 FYN GIMAP1 GP6 GRB2 HCK LAT LGALS3 LYN MIP NSG1 PIK3R1 SERP2 SHC1 SYK UBQLN1 UPK2	6 interacting genes: FCER1G ITIH2 LMNA MESD MS4A2 PDHB
Entrez ID		2212	2205
HPRD ID		00906	00917
Ensembl ID		ENSG00000143226	ENSG00000179639
Uniprot IDs		P12318	P12319
PDB IDs		1FCG 1H9V 3D5O 3RY4 3RY5 3RY6	1ALS 1ALT 1F2Q 1F6A 1J86 1J87 1J88 1J89 1RPQ 2Y7Q
Enriched GO Terms of Interacting Partners?
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