RNF152 and TSPAN12

Data Source:
BioGRID (two hybrid)

		RNF152	TSPAN12
Description		ring finger protein 152	tetraspanin 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Integral Component Of Organelle Membrane	Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Small GTPase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Wnt-activated Receptor Activity
	Biological Process	Apoptotic Process Positive Regulation Of Autophagy Protein Ubiquitination Cellular Response To Amino Acid Starvation Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Negative Regulation Of TORC1 Signaling	Angiogenesis Cell Surface Receptor Signaling Pathway Retina Layer Formation Wnt Signaling Pathway Regulation Of Angiogenesis Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Pathways		E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases			Familial exudative vitreoretinopathy (FEVR), including: Exudative vitreoretinopathy 1 (EVR1); Exudative vitreoretinopathy2, X-linked (EVR2); Exudative vitreoretinopathy 4 (EVR4); Exudative vitreoretinopathy 5 (EVR5); Norrie disease (ND)
GWAS		Estimated glomerular filtration rate ( 31015462 30604766) Glomerular filtration rate (creatinine) ( 28452372 26831199)	Bitter alcoholic beverage consumption ( 31046077) Heel bone mineral density ( 30598549)
Interacting Genes		10 interacting genes: CROCC EBP GJA8 KIR2DL3 RHEB RRAGA TSPAN12 UBE2E1 UBE2N UBE2W	21 interacting genes: CDS2 CTXN3 CXCL16 CYBC1 EMP3 GPR25 GPR37L1 IGFBP5 MARCHF2 MGST3 NINJ2 PMP22 RFT1 RNF152 STX8 TEX264 TFCP2 TMEM140 TMEM147 TMEM182 TMEM218
Entrez ID		220441	23554
HPRD ID		11514	15509
Ensembl ID		ENSG00000176641	ENSG00000106025
Uniprot IDs		Q8N8N0	A0A024R740 O95859
PDB IDs
Enriched GO Terms of Interacting Partners?
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