EFEMP1 and ANAPC11

Data Source:
BioGRID (two hybrid)

		EFEMP1	ANAPC11
Description		EGF containing fibulin extracellular matrix protein 1	anaphase promoting complex subunit 11
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome	Nucleus Nucleoplasm Anaphase-promoting Complex Nucleolus Cytosol Cullin-RING Ubiquitin Ligase Complex
	Molecular Function	Epidermal Growth Factor-activated Receptor Activity Epidermal Growth Factor Receptor Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Growth Factor Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity Cullin Family Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Epidermal Growth Factor Receptor Signaling Pathway Visual Perception Peptidyl-tyrosine Phosphorylation Negative Regulation Of Chondrocyte Differentiation Camera-type Eye Development Embryonic Eye Morphogenesis Post-embryonic Eye Morphogenesis	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)
GWAS		Amyotrophic lateral sclerosis ( 19451621) Blood protein levels ( 30072576) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Carpal tunnel syndrome ( 30833571) Childhood ear infection ( 27182965 28928442) Chronic venous disease ( 28374850) Deep white matter hyperintensities ( 32517579) Diastolic blood pressure ( 30578418) Diverticular disease ( 30177863) FEV1 ( 30804560) Height ( 28552196 20881960 25282103 25429064 19396169 19893584 23563607 31562340 18391951 18391952 20397748 20189936) Hip circumference adjusted for BMI ( 25673412) Inguinal hernia ( 26686553) Intraocular pressure ( 29617998 29785010 30054594 29235454) Joint mobility (Beighton score) ( 27182965) Lung function (FEV1/FVC) ( 30804560) Lung function (forced vital capacity) ( 24929828) Lung function (FVC) ( 30804560) Metabolite levels ( 23823483) Optic cup area ( 25631615 28073927) Pelvic organ prolapse ( 32184442) Pelvic organ prolapse (moderate/severe) ( 26545240) Periventricular white matter hyperintensities ( 32517579) Pulse pressure ( 27841878 30578418) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 26785701 25673412 28448500) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218) White matter hyperintensity volume ( 29752348 30659137) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		42 interacting genes: ANAPC11 ARAF ATN1 ATXN7 BAG4 BAG5 BAG6 CACNA1A CLPP CRYBA4 CYSRT1 DDIAS ERRFI1 FAM110A GFI1B HOXA1 HSD3B7 IGFBP6 KHDRBS1 KRTAP19-2 KRTAP21-2 KRTAP6-1 LCE1C LCE2C LCE3A LCE3D MEOX2 MKRN3 MSRB3 NOS3 NR4A3 RAF1 RERE RIC8A SGTA SLPI SOCS6 TIMP3 TNIP1 TRAF2 TXNDC5 UBQLN2	55 interacting genes: ANAPC10 ANAPC2 ANAPC4 BANP BEND2 CAPN11 CCNB1 CDC16 CDC20 CREB5 CRYBA2 CUL5 CYSRT1 DTX2 EFEMP1 EFEMP2 FBXO5 FRS3 FZR1 GPANK1 HSD3B7 IQUB KRTAP11-1 KRTAP13-2 KRTAP19-2 KRTAP3-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 MAK MGAT5B MLKL NKD2 OXER1 P4HA3 PRKAA2 PRKAB2 PTTG1 RBPMS RNF111 TCEANC TEX37 TLE5 TRIM65 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2K UBE2L1 UBE2S UBE2U WWOX ZAP70
Entrez ID		2202	51529
HPRD ID		03331	12452
Ensembl ID		ENSG00000115380	ENSG00000141552
Uniprot IDs		A0A0S2Z3V1 A0A0S2Z4F1 B2R6M6 Q12805	A0A024R8S1 Q9NYG5
PDB IDs			2MT5 4R2Y 4UI9 5A31 5G04 5G05 5JG6 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5
Enriched GO Terms of Interacting Partners?
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