PHF1 and DPF1

Data Source:
BioGRID (two hybrid)

		PHF1	DPF1
Description		PHD finger protein 1	double PHD fingers 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome ESC/E(Z) Complex Site Of Double-strand Break	Cytoplasm NBAF Complex
	Molecular Function	RNA Polymerase II Transcription Corepressor Binding DNA Binding Chromatin Binding Protein Binding Methylated Histone Binding Identical Protein Binding Metal Ion Binding Histone Methyltransferase Binding	Transcription Coregulator Activity Zinc Ion Binding Histone Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Chromatin Organization Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Histone H3-K27 Methylation Positive Regulation Of Histone H3-K27 Methylation	Apoptotic Process Nervous System Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		PRC2 methylates histones and DNA
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Refractive error ( 32231278)	Amyotrophic lateral sclerosis (sporadic) ( 24529757)
Interacting Genes		77 interacting genes: ABI2 ARID5A ARRDC3 ATXN7L1 AVPI1 BHLHB9 BHLHE40 BIRC7 BOLL C11orf49 CALCOCO2 DISC1 DPF1 DYSF EFHC2 EZH2 FHL2 FOSB GOLGA6L9 GPKOW H3C1 H3C10 H3C11 H3C12 H3C2 H3C3 H3C6 H3C7 H3C8 H4C1 HOMEZ HSD17B14 INCA1 IRAK1BP1 KIAA0408 KRT40 LBX1 LZTS2 MAGED1 MDFI MEOX2 MORN3 NAB2 NEK6 PATZ1 PDLIM7 PFDN5 PIBF1 PRR20A PRR20B PRR20C PRR20D PRR20E RBBP8NL RBPMS SMG9 SORBS3 SPAG8 TFCP2 TFIP11 THAP1 TLE5 TNS2 TOX2 TP53BP2 TRIM23 USP54 VAC14 ZBTB10 ZBTB16 ZIM2 ZNF500 ZNF526 ZNF688 ZNF71 ZRANB1 ZSCAN32	3 interacting genes: PHF1 PTGER4 RPN1
Entrez ID		5252	8193
HPRD ID		04195	03393
Ensembl ID		ENSG00000112511	ENSG00000011332
Uniprot IDs		A0A140VJR4 A0A1U9X8A3 O43189	C8C3P2 E9PDV3 Q6PJ73 Q92782
PDB IDs		2E5P 2M0O 4HCZ 5XFN 5XFO 5XFP 6WAT 6WAV
Enriched GO Terms of Interacting Partners?
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