EYA3 and SIX5

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		EYA3	SIX5
Description		EYA transcriptional coactivator and phosphatase 3	SIX homeobox 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Centrosome	Chromatin Nucleus Transcription Regulator Complex Cytoplasm
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Double-strand Break Repair Multicellular Organism Development Visual Perception Anatomical Structure Morphogenesis Response To Ionizing Radiation Histone Dephosphorylation Cell Differentiation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of DNA Repair Anatomical Structure Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Lens Development In Camera-type Eye Regulation Of Transcription By RNA Polymerase II Spermatid Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases			Contiguous gene deletion syndrome involving EYA1, including: Oto-facio-cervical syndrome (OFC); Branchiootic syndrome 1 (BOS1); Branchio-oto-renal syndrome (BOR)
GWAS		Plasma trimethylamine N-oxide levels ( 28439531) Total cholesterol levels ( 30275531)	Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143)
Interacting Genes		7 interacting genes: CRK DACH1 SIX1 SIX2 SIX4 SIX5 ZDHHC17	3 interacting genes: ATXN1 EYA3 HMGB1
Entrez ID		2140	147912
HPRD ID		09042	09024
Ensembl ID		ENSG00000158161	ENSG00000177045
Uniprot IDs		Q99504	Q8N196
PDB IDs
Enriched GO Terms of Interacting Partners?
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