SIX5 and EYA3

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SIX5	EYA3
Description		SIX homeobox 5	EYA transcriptional coactivator and phosphatase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Centrosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding	Protein Tyrosine Phosphatase Activity Protein Binding Metal Ion Binding
	Biological Process	Lens Development In Camera-type Eye Regulation Of Transcription By RNA Polymerase II Spermatid Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation	Double-strand Break Repair Multicellular Organism Development Visual Perception Anatomical Structure Morphogenesis Response To Ionizing Radiation Histone Dephosphorylation Cell Differentiation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of DNA Repair Anatomical Structure Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases		Contiguous gene deletion syndrome involving EYA1, including: Oto-facio-cervical syndrome (OFC); Branchiootic syndrome 1 (BOS1); Branchio-oto-renal syndrome (BOR)
GWAS		Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143)	Plasma trimethylamine N-oxide levels ( 28439531) Total cholesterol levels ( 30275531)
Interacting Genes		3 interacting genes: ATXN1 EYA3 HMGB1	7 interacting genes: CRK DACH1 SIX1 SIX2 SIX4 SIX5 ZDHHC17
Entrez ID		147912	2140
HPRD ID		09024	09042
Ensembl ID		ENSG00000177045	ENSG00000158161
Uniprot IDs		Q8N196	Q99504
PDB IDs
Enriched GO Terms of Interacting Partners?
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