ESRRB and NCOA3

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		ESRRB	NCOA3
Description		estrogen related receptor beta	nuclear receptor coactivator 3
Image
GO Annotations	Cellular Component	Chromatin Condensed Chromosome Nucleus Nucleoplasm Cytoplasm Cytosol Integrator Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Steroid Binding Transcription Factor Binding Zinc Ion Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Complex Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Nuclear Receptor Binding Nuclear Receptor Coactivator Activity Nuclear Hormone Receptor Binding Thyroid Hormone Receptor Binding Protein Dimerization Activity Protein N-terminus Binding Disordered Domain Specific Binding
	Biological Process	Embryonic Placenta Development Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Stem Cell Division Stem Cell Population Maintenance Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Cell Dedifferentiation Photoreceptor Cell Maintenance Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development Positive Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription Involved In G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Division Negative Regulation Of Stem Cell Differentiation	Histone Acetylation Cellular Response To Hormone Stimulus Receptor Transactivation Cell Dedifferentiation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Division
Pathways		Nuclear Receptor transcription pathway	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Activation of anterior HOX genes in hindbrain development during early embryogenesis MAPK6/MAPK4 signaling Estrogen-dependent gene expression
Drugs		Diethylstilbestrol Genistein Flavone
Diseases
GWAS		Maximal oxygen uptake response ( 25729143) Sphingomyelin 24:0 levels ( 31560688) Tuberculosis ( 30287856)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Osteoarthritis (hip) ( 23989986) Response to treatment for acute lymphoblastic leukemia ( 19176441)
Interacting Genes		8 interacting genes: ESRRG HIF1A HSP90AA1 HSP90AB1 NCOA2 NCOA3 NRIP1 SP1	82 interacting genes: ABL1 ANKRD11 AR ARNT2 ATAD2 BABAM2 BMP6 BMP7 BRCA1 CCND1 CDKN3 CHUK CREBBP CSNK1E DCTN6 DDX17 DDX5 E2F1 EP300 ESR1 ESR2 ESRRA ESRRB ETV1 FOS GSK3B GTF2B H3-4 H4-16 HNF1A IKBKB IKBKG IQCK JUN KAT2B MAPK1 MAPK14 MAPK8 MMS19 MN1 MRTFA MRTFB NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR1I2 NR1I3 NR2F1 NR3C1 NR4A1 NR5A2 PGR PIN1 PPARA PPARD PPARG PRKCZ PRMT1 PSMB9 PSME3 RARA RARB RARG RELA RXRA RXRB SLC22A2 SMARCE1 SPOP SUFU SUMO1 TBP THRB TP53 TP53BP1 VDR YWHAH YWHAQ
Entrez ID		2103	8202
HPRD ID		03700	03570
Ensembl ID		ENSG00000119715	ENSG00000124151
Uniprot IDs		O95718	Q59EE8 Q9Y6Q9
PDB IDs		1LO1 6LIT 6LN4	1KBH 3L3X 3L3Z 6ES7 6SQC
Enriched GO Terms of Interacting Partners?
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