AK4 and EPHA8

Data Source:
BioGRID (two hybrid)

		AK4	EPHA8
Description		adenylate kinase 4	EPH receptor A8
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix	Plasma Membrane Integral Component Of Plasma Membrane Early Endosome Membrane Neuron Projection Receptor Complex
	Molecular Function	Adenylate Kinase Activity Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding GTP Binding Nucleoside Triphosphate Adenylate Kinase Activity Nucleoside Monophosphate Kinase Activity	Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity ATP Binding
	Biological Process	Liver Development Regulation Of Oxidative Phosphorylation Nucleoside Diphosphate Phosphorylation ADP Biosynthetic Process Brain Development Nucleoside Triphosphate Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Response To Drug AMP Metabolic Process ATP Metabolic Process GTP Metabolic Process Nucleoside Monophosphate Phosphorylation Cellular Response To Hypoxia Regulation Of ATP Biosynthetic Process	Substrate-dependent Cell Migration Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Neuron Remodeling Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Neuron Projection Development Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway Cellular Response To Follicle-stimulating Hormone Stimulus
Pathways		Interconversion of nucleotide di- and triphosphates	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs			Fostamatinib
Diseases
GWAS		Idiopathic osteonecrosis of the femoral head ( 28000841)
Interacting Genes		4 interacting genes: APP CEP19 EPHA8 KEAP1	12 interacting genes: AK4 DARS2 EFNA1 EFNA4 EFNA5 FYN G3BP1 LRRK1 PIK3CG PSMC5 PTPRD ZNF746
Entrez ID		205	2046
HPRD ID		00048	01493
Ensembl ID		ENSG00000162433	ENSG00000070886
Uniprot IDs		F8VS11 P27144	P29322
PDB IDs		2AR7 2BBW 3NDP	1UCV 1X5L 3KUL
Enriched GO Terms of Interacting Partners?
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