EPHA5 and EFNA3

Data Source:
HPRD (in vivo)

		EPHA5	EFNA3
Description		EPH receptor A5	ephrin A3
Image			No pdb structure
GO Annotations	Cellular Component	Rough Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Axon Dendrite Neuron Projection Neuronal Cell Body Receptor Complex Perinuclear Region Of Cytoplasm	Plasma Membrane Anchored Component Of Membrane Intrinsic Component Of Plasma Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity ATP Binding	Transmembrane-ephrin Receptor Activity Protein Binding Ephrin Receptor Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Peptidyl-tyrosine Phosphorylation CAMP-mediated Signaling Hippocampus Development Positive Regulation Of CREB Transcription Factor Activity Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Kinase Activity Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Neuron Development Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus	Cell-cell Signaling Axon Guidance Negative Regulation Of Angiogenesis Regulation Of Neuron Differentiation Ephrin Receptor Signaling Pathway Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs		Dasatinib Fostamatinib
Diseases
GWAS		Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) General risk tolerance (MTAG) ( 30643258) HIV-1 viral setpoint ( 22174851) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Severe skin toxicity response to cetuximab in colorectal cancer ( 30557370) Urate levels (BMI interaction) ( 25811787)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cataracts (operation) ( 31816047) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Optic disc size ( 31809533) Prostate cancer ( 23535732) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urinary albumin excretion ( 30220432)
Interacting Genes		8 interacting genes: DUSP21 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 ERBB2 NEDD4	11 interacting genes: EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 KRTAP1-1 KRTAP10-3 LCE2C MEOX2 NOTCH2NLA PRSS23
Entrez ID		2044	1944
HPRD ID		02474	03225
Ensembl ID		ENSG00000145242	ENSG00000143590
Uniprot IDs		A0A384MU00 B7ZKJ3 B7ZKW7 F8VP57 F8W9W0 P54756 Q59FT4	P52797
PDB IDs		2R2P 4ET7
Enriched GO Terms of Interacting Partners?
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