EFNA3 and EPHA5

Data Source:
HPRD (in vivo)

		EFNA3	EPHA5
Description		ephrin A3	EPH receptor A5
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Anchored Component Of Membrane Intrinsic Component Of Plasma Membrane	Rough Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Axon Dendrite Neuron Projection Neuronal Cell Body Receptor Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Transmembrane-ephrin Receptor Activity Protein Binding Ephrin Receptor Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity ATP Binding
	Biological Process	Cell-cell Signaling Axon Guidance Negative Regulation Of Angiogenesis Regulation Of Neuron Differentiation Ephrin Receptor Signaling Pathway Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Peptidyl-tyrosine Phosphorylation CAMP-mediated Signaling Hippocampus Development Positive Regulation Of CREB Transcription Factor Activity Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Kinase Activity Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Neuron Development Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs			Dasatinib Fostamatinib
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cataracts (operation) ( 31816047) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Optic disc size ( 31809533) Prostate cancer ( 23535732) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urinary albumin excretion ( 30220432)	Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) General risk tolerance (MTAG) ( 30643258) HIV-1 viral setpoint ( 22174851) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Severe skin toxicity response to cetuximab in colorectal cancer ( 30557370) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		11 interacting genes: EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 KRTAP1-1 KRTAP10-3 LCE2C MEOX2 NOTCH2NLA PRSS23	8 interacting genes: DUSP21 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 ERBB2 NEDD4
Entrez ID		1944	2044
HPRD ID		03225	02474
Ensembl ID		ENSG00000143590	ENSG00000145242
Uniprot IDs		P52797	A0A384MU00 B7ZKJ3 B7ZKW7 F8VP57 F8W9W0 P54756 Q59FT4
PDB IDs			2R2P 4ET7
Enriched GO Terms of Interacting Partners?
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