EPB41 and MYL1

Data Source:
HPRD (in vitro)

		EPB41	MYL1
Description		erythrocyte membrane protein band 4.1	myosin light chain 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Spectrin-associated Cytoskeleton Basolateral Plasma Membrane Nuclear Body Cell Junction Cortical Cytoskeleton Protein-containing Complex Intercellular Bridge Mitotic Spindle Cell Cortex Region	Cytosol Muscle Myosin Complex Myofibril Sarcomere
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Protein C-terminus Binding Spectrin Binding Protein N-terminus Binding Phosphoprotein Binding	Calcium Ion Binding Structural Constituent Of Muscle
	Biological Process	Cell Cycle Regulation Of Cell Shape Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Positive Regulation Of Protein Binding Cell Division Regulation Of Calcium Ion Transport Protein-containing Complex Assembly Regulation Of Intestinal Absorption Positive Regulation Of Protein Localization To Cell Cortex	Muscle Contraction Muscle Filament Sliding Cardiac Muscle Contraction
Pathways		Neurexins and neuroligins	Striated Muscle Contraction
Drugs
Diseases		Hereditary elliptocytosis (HE)
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Tourette syndrome ( 30818990)	Serum metabolite levels ( 23093944)
Interacting Genes		39 interacting genes: ACTA1 APP BCAM C2CD2L CASK CD44 CENPJ CLNS1A CRYAB DLG1 DRD2 DRD3 EGFR EIF3G EPB42 FKBP2 GDI1 GYPC KPNA2 MACROD1 MYL1 NPPA NUMA1 PRKCB RWDD2B SEC14L1 SLC4A1 SMAD3 SPTAN1 SPTB SPTBN1 TJP2 TPM1 TUBA4A U2AF1 U2AF2 YWHAB YWHAQ ZCCHC10	7 interacting genes: ACTA1 ACTA2 ANKRD1 APP EPB41 IQGAP1 UBC
Entrez ID		2035	4632
HPRD ID		00558	01180
Ensembl ID		ENSG00000159023	ENSG00000168530
Uniprot IDs		A0A2R8Y7Y3 P11171 Q1WWM3 Q29RX4 Q59F12	P05976
PDB IDs		1GG3 2RQ1 3QIJ
Enriched GO Terms of Interacting Partners?
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