PRIMPOL and CDKN2D

Data Source:
BioGRID (two hybrid)

		PRIMPOL	CDKN2D
Description		primase and DNA directed polymerase	cyclin dependent kinase inhibitor 2D
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GO Annotations	Cellular Component	Nucleus Replication Fork Mitochondrial Matrix	Nucleus Nucleoplasm Cytoplasm Cytosol Cyclin D2-CDK4 Complex
	Molecular Function	Chromatin Binding DNA-directed DNA Polymerase Activity DNA Primase Activity Protein Binding Zinc Ion Binding Manganese Ion Binding	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding
	Biological Process	Mitochondrial DNA Replication DNA Replication, Synthesis Of RNA Primer Response To UV Translesion Synthesis Replication Fork Processing Error-prone Translesion Synthesis Mitochondrial DNA Repair R-loop Disassembly	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair Cell Cycle Arrest Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Response To UV Negative Regulation Of Cell Growth Response To Retinoic Acid Response To Vitamin D Negative Regulation Of Phosphorylation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Autophagic Cell Death Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1
Drugs
Diseases
GWAS		Blood protein levels ( 28240269)	Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		5 interacting genes: CDKN2D MPP1 NAV1 PSMA1 RPA1	63 interacting genes: APP BRCA1 BTG1 C1orf94 C5orf49 CCND3 CDK4 CDK6 CGGBP1 CTBP1 DDIT4L DMRTB1 DYNLT2B EIF4G1 FAM228A FAM86C1P FHL3 GATAD2B GLYR1 GORASP2 GSC2 HSD17B14 IKZF3 INCA1 KRT75 LNX1 LONRF1 LSM3 MEI4 MEOX2 MSS51 MTF2 NDUFB7 NIF3L1 NME4 NMI NR4A1 NR4A2 NR4A3 PICK1 PRDX5 PRIMPOL PSMA1 QKI REL RUFY4 SAXO1 SDCBP SH3GLB1 SH3GLB2 TBC1D17 TEX11 THAP1 TSG101 TSGA10IP UQCC2 VGLL1 YPEL3 ZBTB32 ZNF396 ZNF620 ZNF688 ZNF774
Entrez ID		201973	1032
HPRD ID		08742	02957
Ensembl ID		ENSG00000164306	ENSG00000129355
Uniprot IDs		A0A5S6SZ32 Q96LW4	A0A024R796 P55273
PDB IDs		5L2X 5N85 5N8A	1BD8 1BI8
Enriched GO Terms of Interacting Partners?
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