CTTN and SPRR2A

Data Source:
BioGRID (pull down)

		CTTN	SPRR2A
Description		cortactin	small proline rich protein 2A
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Podosome Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Actin Filament Plasma Membrane Clathrin-coated Pit Focal Adhesion Cell Cortex Voltage-gated Potassium Channel Complex Lamellipodium Growth Cone Site Of Polarized Growth Cortical Cytoskeleton Cortical Actin Cytoskeleton Dendritic Spine Intracellular Membrane-bounded Organelle Mitotic Spindle Midzone	Cornified Envelope Cytoplasm Cytosol
	Molecular Function	Protein Binding Profilin Binding Cadherin Binding Actin Filament Binding	Protein Binding
	Biological Process	Intracellular Protein Transport Receptor-mediated Endocytosis Substrate-dependent Cell Migration, Cell Extension Actin Filament Polymerization Regulation Of Axon Extension Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Positive Regulation Of Smooth Muscle Contraction Focal Adhesion Assembly Neuron Projection Morphogenesis Cell Motility Membrane Organization Dendritic Spine Maintenance Lamellipodium Organization Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Epidermis Development Keratinocyte Differentiation Cornification
Pathways		RHO GTPases activate PAKs Clathrin-mediated endocytosis	Formation of the cornified envelope
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		42 interacting genes: ACD ACTA1 ACTG1 ACTR3 ANKZF1 ARHGAP17 ARHGAP8 CASP3 CD2AP CHD3 CTNND1 CTNND2 CTTNBP2 DNM1 DNM2 EGFR FER FGD1 GRB2 HAX1 HDAC6 HIP1R KCNA2 KEAP1 MET MYLK NHSL2 RPL9 SDC3 SH3BP2 SHANK2 SIRT1 SMURF1 SPRR2A SRC SYK TINF2 TJP1 TNK2 TRIM15 WASL WIPF1	10 interacting genes: ABL1 AKT2 CRK CTTN DLG4 EVPL HCK ITK PEX13 YES1
Entrez ID		2017	6700
HPRD ID		01268	01649
Ensembl ID		ENSG00000085733	ENSG00000241794
Uniprot IDs		A0A024R5M3 Q14247 Q53HG7	P35326
PDB IDs		1X69 2D1X
Enriched GO Terms of Interacting Partners?
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