SPRR2A and EVPL

Data Source:
HPRD (in vivo)

		SPRR2A	EVPL
Description		small proline rich protein 2A	envoplakin
Image		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol	Cornified Envelope Cytoplasm Cytosol Intermediate Filament Membrane Desmosome Intermediate Filament Cytoskeleton Extracellular Exosome
	Molecular Function	Protein Binding	Structural Molecule Activity Intermediate Filament Binding Cadherin Binding
	Biological Process	Epidermis Development Keratinocyte Differentiation Cornification	Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Wound Healing Intermediate Filament Cytoskeleton Organization Cornification
Pathways		Formation of the cornified envelope	Formation of the cornified envelope
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)	Deep white matter hyperintensities ( 32517579) Depressive symptom improvement ( 30468137) L-selectin levels ( 25576479) Metabolite levels ( 23823483) Periventricular white matter hyperintensities ( 32517579)
Interacting Genes		10 interacting genes: ABL1 AKT2 CRK CTTN DLG4 EVPL HCK ITK PEX13 YES1	14 interacting genes: CSTA DSP IVL KRT1 KRT10 KRT2 KRT5 LORICRIN PI3 PLEKHA5 PPL PSORS1C2 SPRR2A SPRR3
Entrez ID		6700	2125
HPRD ID		01649	03352
Ensembl ID		ENSG00000241794	ENSG00000167880
Uniprot IDs		P35326	B7ZLH8 K7EKI0 Q92817
PDB IDs			4QMD
Enriched GO Terms of Interacting Partners?
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