ZNF837 and EHMT2

Data Source:
BioGRID (two hybrid)

		ZNF837	EHMT2
Description		zinc finger protein 837	euchromatic histone lysine methyltransferase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Chromatin Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding Metal Ion Binding	RNA Polymerase II Transcription Corepressor Binding P53 Binding Protein Binding Zinc Ion Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Histone Methyltransferase Activity (H3-K27 Specific) C2H2 Zinc Finger Domain Binding Promoter-specific Chromatin Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA Replication DNA Methylation Cellular Response To Starvation Histone Methylation Peptidyl-lysine Dimethylation Histone Lysine Methylation Histone H3-K9 Methylation Negative Regulation Of G0 To G1 Transition Histone H3-K27 Methylation Regulation Of Signal Transduction By P53 Class Mediator
Pathways			Senescence-Associated Secretory Phenotype (SASP) PKMTs methylate histone lysines ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Methylation RNA Polymerase I Transcription Initiation Transcriptional Regulation by VENTX Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS			Anti-thyroid drug induced agranulocytosis ( 27157822) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Chronic hepatitis B infection ( 25802187 23760081) Chronotype ( 30696823) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Economic and political preferences (environmentalism) ( 22566634) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 28067908) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Takayasu arteritis ( 25604533) Type 2 diabetes ( 29358691) Ulcerative colitis ( 28067908) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) White blood cell count ( 32888494)
Interacting Genes		77 interacting genes: BAHD1 CARD10 CATSPER1 CCDC125 CCDC136 CCNDBP1 CDC37 CHIC2 CLK2 CYSRT1 DHX57 DVL3 EFEMP2 EHMT2 FSD2 GOLGA6L9 GPATCH2L HOXA1 KHDRBS2 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP4-11 KRTAP4-12 KRTAP4-5 KRTAP5-9 MDFI MTUS2 MYO15B NBPF19 NOTCH2NLA PCSK5 PHF19 PPARD PPP1R37 PRPF31 RBMY1F RBMY1J RSPO2 SPRED2 SPRY1 TCEANC TNS2 TRIM41 TRMT2A UBE2I VWC2 ZBTB24 ZBTB48 ZBTB8A ZNF121 ZNF124 ZNF165 ZNF17 ZNF202 ZNF250 ZNF275 ZNF330 ZNF408 ZNF417 ZNF473 ZNF497 ZNF524 ZNF526 ZNF552 ZNF587 ZNF639 ZNF648 ZNF655 ZNF764 ZNF792 ZNF835 ZRANB1 ZSCAN21	59 interacting genes: ABHD17A ANKRD28 ATF7IP AURKA CACNA1A CCDC33 CHCHD2 CSNK2A1 CUX1 DNMT3A E4F1 EIF4A3 EPDR1 ESR1 FAM161A H1-1 H1-5 H3-3B H3-4 H3C1 H3C14 H3C15 HGS HIC2 ITGB5 KLF12 KLF3 KLF6 LASP1 LIG1 LIMS1 LMO2 LNX1 MX2 NAA10 NAA11 NAPRT PLOD3 PRRC2B PSMA1 PTGER4 RD3 RELB RERE RPA1 RUVBL2 THAP7 TP53 VEZF1 WIZ XAGE2 ZBTB38 ZNF446 ZNF462 ZNF512B ZNF688 ZNF775 ZNF785 ZNF837
Entrez ID		116412	10919
HPRD ID			06854
Ensembl ID		ENSG00000152475	ENSG00000204371
Uniprot IDs		Q96EG3	A0A024RCN9 A2ABF8 B7Z852 Q59FM7 Q96KQ7
PDB IDs			2O8J 3DM1 3K5K 3RJW 4NVQ 5JHN 5JIN 5JIY 5JJ0 5T0K 5T0M 5TTF 5TUY 5V9I 5VSC 5VSE 6MM1
Enriched GO Terms of Interacting Partners?
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