EIF4B and ACD

Data Source:
BioGRID (two hybrid)

		EIF4B	ACD
Description		eukaryotic translation initiation factor 4B	ACD shelterin complex subunit and telomerase recruitment factor
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GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleoplasm Telomerase Holoenzyme Complex Nuclear Body Shelterin Complex
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding RNA Strand Annealing Activity RNA Strand-exchange Activity Ribosomal Small Subunit Binding	Protein Binding Telomeric DNA Binding Protein-containing Complex Binding DNA Polymerase Binding
	Biological Process	Formation Of Translation Preinitiation Complex Translational Initiation Regulation Of Translational Initiation Eukaryotic Translation Initiation Factor 4F Complex Assembly	Telomere Maintenance Intracellular Protein Transport Telomere Maintenance Via Telomerase Telomere Capping Protection From Non-homologous End Joining At Telomere Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomerase Activity Positive Regulation Of Single-stranded Telomeric DNA Binding Protein Localization To Chromosome, Telomeric Region Establishment Of Protein Localization To Telomere
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Prostate cancer ( 21743057)	Hemoglobin levels ( 32327693) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		18 interacting genes: ACD CASP3 CSNK2A1 EIF3A EIF4E LAMTOR5 LINC01554 PABPC1 PAK2 POT1 RHOU RPS6KB1 SFN SMAD3 SRPK2 TERF1 TINF2 USP11	63 interacting genes: ACTB ADPRH AFAP1L2 AIPL1 ANKMY2 ANXA8L1 APOBEC3F BAG3 CKB CTTN DBN1 DBNL DCX DPYSL3 EIF3G EIF4B ENO2 ENSA FAM131B FKBP6 GAPDH HSP90AB1 IPO5 IVL LASP1 LDHA LGALSL LLGL1 LRRC25 NCDN NTAQ1 NUDC NUDCD2 PAGE2 PDLIM2 PEX5 PFKP PGM2 POT1 RBKS RECQL4 RGS3 RPSA SBDS STIP1 STUB1 SULT1C2 TAGLN TBC1D10A TBCD TINF2 TOMM34 TRIM15 TRIM16 TRIM55 TRIM63 TUBB2A TUBB4B USP7 XRCC6 YWHAE ZFP36L1 ZNF790
Entrez ID		1975	65057
HPRD ID		04892	12417
Ensembl ID		ENSG00000063046	ENSG00000102977
Uniprot IDs		B4DRM3 E7EX17 P23588 Q7Z5Y0	A0A590TQL1 Q96AP0
PDB IDs		1WI8 2J76 6FEC	2I46 5H65 5I2X 5I2Y 5UN7 5XYF
Enriched GO Terms of Interacting Partners?
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