EIF4B and EIF4E

Data Source:
HPRD (in vitro)

		EIF4B	EIF4E
Description		eukaryotic translation initiation factor 4B	eukaryotic translation initiation factor 4E
Image
GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex	P-body Nucleus Cytoplasm Cytosol MRNA Cap Binding Complex Cytoplasmic Stress Granule Eukaryotic Translation Initiation Factor 4F Complex RISC Complex Chromatoid Body Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Postsynaptic Cytosol
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding RNA Strand Annealing Activity RNA Strand-exchange Activity Ribosomal Small Subunit Binding	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding Translation Initiation Factor Activity Protein Binding Enzyme Binding Eukaryotic Initiation Factor 4G Binding Repressing Transcription Factor Binding
	Biological Process	Formation Of Translation Preinitiation Complex Translational Initiation Regulation Of Translational Initiation Eukaryotic Translation Initiation Factor 4F Complex Assembly	G1/S Transition Of Mitotic Cell Cycle Behavioral Fear Response RNA Export From Nucleus MRNA Export From Nucleus Translational Initiation Regulation Of Translation Negative Regulation Of Autophagy Viral Process Negative Regulation Of Translation Stem Cell Population Maintenance Lung Development Negative Regulation Of Neuron Differentiation Positive Regulation Of Mitotic Cell Cycle Cellular Response To Dexamethasone Stimulus Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript mTORC1-mediated signalling Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs			7-methyl-GpppA 7-methyl-7,8-dihydroguanosine-5'-diphosphate 7-methyl-guanosine-5'-triphosphate LY2275796 S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Prostate cancer ( 21743057)	Alcohol consumption (drinks per week) ( 30643258 30679032) Daytime sleep phenotypes ( 27126917) HDL cholesterol levels ( 32203549) Mean arterial pressure x educational attainment (graduated college) interaction (2df) ( 32372009) Menopause (age at onset) ( 29773799) Sensation seeking ( 30718321)
Interacting Genes		18 interacting genes: ACD CASP3 CSNK2A1 EIF3A EIF4E LAMTOR5 LINC01554 PABPC1 PAK2 POT1 RHOU RPS6KB1 SFN SMAD3 SRPK2 TERF1 TINF2 USP11	26 interacting genes: APP BIRC2 CD83 EIF4B EIF4EBP1 EIF4EBP2 EIF4EBP3 EIF4ENIF1 EIF4G1 EIF4G2 EIF4G3 EMX2 GEMIN5 KANK2 MAPKAPK5 MKNK1 MKNK2 PML PRDM4 PRKCA PRKCB PRKCG PTEN TDO2 TRIM27 UBXN11
Entrez ID		1975	1977
HPRD ID		04892	00591
Ensembl ID		ENSG00000063046	ENSG00000151247
Uniprot IDs		B4DRM3 E7EX17 P23588 Q7Z5Y0	D6RBW1 P06730 Q32Q75 X5D7E3
PDB IDs		1WI8 2J76 6FEC	1IPB 1IPC 1WKW 2GPQ 2V8W 2V8X 2V8Y 2W97 3AM7 3TF2 3U7X 4AZA 4BEA 4DT6 4DUM 4TPW 4TQB 4TQC 4UED 5EHC 5EI3 5EIR 5EKV 5GW6 5T46 5ZJY 5ZJZ 5ZK5 5ZK7 5ZK9 5ZML
Enriched GO Terms of Interacting Partners?
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