DCP1B and LSM8

Data Source:
BioGRID (two hybrid)

		DCP1B	LSM8
Description		decapping mRNA 1B	LSM8 homolog, U6 small nuclear RNA associated
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytosol Membrane Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm U6 SnRNP U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Lsm2-8 Complex
	Molecular Function	MRNA Binding Protein Binding Enzyme Activator Activity Hydrolase Activity Enzyme Regulator Activity	RNA Binding Protein Binding U6 SnRNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Positive Regulation Of Catalytic Activity Exonucleolytic Catabolism Of Deadenylated MRNA	MRNA Splicing, Via Spliceosome RNA Metabolic Process
Pathways		mRNA decay by 5' to 3' exoribonuclease	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Grapefruit juice consumption ( 31046077) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Response to gemcitabine in pancreatic cancer ( 22142827) Survival in pancreatic cancer ( 28470677)	Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Glaucoma (primary open-angle) ( 29891935) Intraocular pressure ( 29617998) Plasma anti-thyroid peroxidase levels ( 29678681) Positive urgency ( 30718321) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Triglyceride levels ( 30108155)
Interacting Genes		10 interacting genes: DCP2 EDC3 EXOSC6 LSM8 MIR15B NSMAF SMAD4 UPF2 XRN1 ZFP36	49 interacting genes: ARNT BCKDK COL23A1 DBF4 DCP1A DCP1B DPAGT1 ECHDC2 EFTUD2 EXOSC10 EXOSC6 FERMT3 GMPPA GTF2I HSPA9 IFNLR1 IGHMBP2 ISOC2 ITSN2 KCTD3 LSM2 LSM3 LSM5 LSM6 LSM7 MAPK8IP2 MGA MINDY1 MPRIP MRPL48 MTHFR NAGK NME4 PDCD2 PGD PHF11 RBM5 RPL24 RSC1A1 RSL24D1 SEPTIN10 SEPTIN5 SMU1 SNRNP200 SNRPB SNRPD1 TALDO1 THUMPD3 UPF1
Entrez ID		196513	51691
HPRD ID		13124	06288
Ensembl ID		ENSG00000151065	ENSG00000128534
Uniprot IDs		B4DVJ6 Q8IZD4	A4D0W0 O95777
PDB IDs			3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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