MEGF8 and SYT5

Data Source:
BioGRID (proximity labelling technology)

		MEGF8	SYT5
Description		multiple EGF like domains 8	synaptotagmin 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Integral Component Of Membrane Extracellular Exosome	Plasma Membrane Axon Synaptic Vesicle Membrane Dense Core Granule Neuronal Cell Body Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Exocytic Vesicle Integral Component Of Neuronal Dense Core Vesicle Membrane Proximal Neuron Projection
	Molecular Function	Calcium Ion Binding Protein Binding	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Syntaxin Binding Clathrin Binding Protein Heterodimerization Activity
	Biological Process	Embryonic Heart Tube Morphogenesis Animal Organ Morphogenesis Tissue Development Regulation Of Gene Expression Embryonic Limb Morphogenesis BMP Signaling Pathway Limb Morphogenesis Cell Migration Involved In Gastrulation Negative Regulation Of Smoothened Signaling Pathway Embryonic Skeletal System Morphogenesis Positive Regulation Of Axon Extension Involved In Axon Guidance Epiboly Involved In Gastrulation With Mouth Forming Second Embryonic Heart Tube Left/right Pattern Formation Left/right Pattern Formation Coronary Vasculature Development Determination Of Heart Left/right Asymmetry Determination Of Digestive Tract Left/right Asymmetry Craniofacial Suture Morphogenesis Fasciculation Of Sensory Neuron Axon	Chemical Synaptic Transmission Regulation Of Dopamine Secretion Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Synaptic Vesicle Endocytosis Calcium Ion-regulated Exocytosis Of Neurotransmitter Cellular Response To Calcium Ion
Pathways			Regulation of insulin secretion
Drugs
Diseases
GWAS			Platelet distribution width ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		3 interacting genes: ATN1 CACNA1A GFI1B	6 interacting genes: DNAJC5 HTR6 NRXN1 POLR2E RAB1A SYT3
Entrez ID		1954	6861
HPRD ID		10370	02870
Ensembl ID		ENSG00000105429	ENSG00000129990
Uniprot IDs		Q7Z7M0	A0A024R4N8 O00445 Q4FD32
PDB IDs			5H4Y 5H4Z
Enriched GO Terms of Interacting Partners?
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