EFNA5 and SLC10A2

Data Source:
BioGRID (two hybrid)

		EFNA5	SLC10A2
Description		ephrin A5	solute carrier family 10 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Caveola Anchored Component Of External Side Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane
	Molecular Function	Neurotrophin TRKA Receptor Binding Neurotrophin TRKB Receptor Binding Neurotrophin TRKC Receptor Binding Protein Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Ephrin Receptor Binding	Protein Binding Bile Acid:sodium Symporter Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Apoptotic Process Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Nervous System Development Axon Guidance Regulation Of Cell-cell Adhesion Regulation Of Cell Morphogenesis Regulation Of Actin Cytoskeleton Organization Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Focal Adhesion Assembly Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Substrate Adhesion-dependent Cell Spreading	Sodium Ion Transport Bile Acid And Bile Salt Transport Transmembrane Transport
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	Recycling of bile acids and salts
Drugs			Volixibat
Diseases			Primary bile acid malabsorption
GWAS		Adult body size ( 32376654) Alzheimer's disease biomarkers ( 23419831) Atrial fibrillation ( 29892015) Body mass index ( 26426971) Chronotype ( 30696823) Cocaine dependence ( 31212010) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Dentures ( 31235808) Hippocampal atrophy ( 19668339) Household income (MTAG) ( 31844048) Longitudinal cocaine use ( 31591132) Medial orbital frontal cortex volume ( 31530798) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Neonatal cytokine/chemokine levels (maternal genetic effect) ( 30134952) Non-del(5q) myelodysplastic syndromes ( 31738830) Nose morphology ( 29921221) Number of children ever born ( 27798627) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Sedentary behaviour duration ( 30531941) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) epithelial cell adhesion molecule levels ( 25147954) Esophageal cancer (alcohol interaction) ( 22960999) Gallstone disease ( 30504769) Late-onset Alzheimer's disease ( 27770636) Metabolite levels ( 23823483) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Response to quetiapine in schizophrenia ( 29503163) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		39 interacting genes: ACKR2 AQP2 AQP6 BEST2 CD53 CLDN5 CYB561 EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 EPHA8 EPHB1 EPHB2 FFAR3 GJB1 GPR151 GPR152 GPR161 GPR42 GRIP1 HERPUD2 HIBADH KASH5 MS4A3 RHCG SGPL1 SLC10A2 SLC13A4 SLC16A2 SLC35C2 SRC SSMEM1 TM4SF18 TMEM237 TRHR TSPO2 YIPF6	10 interacting genes: C3orf52 CCL4L2 CTXN3 EFNA5 IFITM3 NRM PSENEN TEX264 TMEM222 UPK1B
Entrez ID		1946	6555
HPRD ID		03324	03189
Ensembl ID		ENSG00000184349	ENSG00000125255
Uniprot IDs		D6RDV5 P52803	Q12908
PDB IDs		2X11 3MX0 4BK5 4BKA 4L0P 4M4R
Enriched GO Terms of Interacting Partners?
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