AGO4 and TNRC6C

Data Source:
BioGRID (pull down)

		AGO4	TNRC6C
Description		argonaute RISC component 4	trinucleotide repeat containing adaptor 6C
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GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Membrane RISC Complex Cytoplasmic Ribonucleoprotein Granule RISC-loading Complex	P-body Nucleoplasm Cytosol
	Molecular Function	Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding MiRNA Binding	RNA Binding Protein Binding
	Biological Process	MRNA Catabolic Process Synaptonemal Complex Assembly Male Meiotic Nuclear Division Wnt Signaling Pathway, Calcium Modulating Pathway Male Gonad Development RNA Secondary Structure Unwinding MiRNA Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Cell Morphogenesis Pre-miRNA Processing Post-transcriptional Gene Silencing By RNA Production Of MiRNAs Involved In Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation MRNA Cleavage Involved In Gene Silencing By MiRNA MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Negative Regulation Of Apoptotic Process Regulation Of Megakaryocyte Differentiation MRNA Cleavage Involved In Gene Silencing By SiRNA	Wnt Signaling Pathway, Calcium Modulating Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Post-transcriptional Gene Silencing By RNA Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Pathways		Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Post-transcriptional silencing by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS			Normal facial asymmetry (angle of deformation score) ( 30631343) Refractive error ( 32231278) Serum uric acid levels ( 29559957) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Uterine fibroid number (single vs multiple) ( 30196971)
Interacting Genes		4 interacting genes: APP TNRC6A TNRC6B TNRC6C	2 interacting genes: AGO4 UBC
Entrez ID		192670	57690
HPRD ID		09559	10026
Ensembl ID		ENSG00000134698	ENSG00000078687
Uniprot IDs		Q9HCK5	Q9HCJ0
PDB IDs		6OON	2DKL 2X04 3KTP
Enriched GO Terms of Interacting Partners?
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