PHC1 and GMNN

Data Source:
HPRD (in vitro)

		PHC1	GMNN
Description		polyhomeotic homolog 1	geminin DNA replication inhibitor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding Repressing Transcription Factor Binding
	Biological Process	Multicellular Organism Development Histone Ubiquitination Negative Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition	G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Replication Negative Regulation Of DNA Replication Animal Organ Morphogenesis Positive Regulation Of Chromatin Binding Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated DNA Replication Preinitiation Complex Assembly Negative Regulation Of DNA-dependent DNA Replication
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	CDT1 association with the CDC6:ORC:origin complex Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Antisaccade task score ( 31596458) Cholesterol, total ( 24097068) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Height ( 31562340) Prepulse inhibition of the startle response ( 31596458) Small cell lung carcinoma ( 28604730) Total cholesterol levels ( 28334899)	Metabolite levels ( 23823483)
Interacting Genes		24 interacting genes: BMI1 FAM9A GMNN HSPA8 PCGF2 PCGF3 PHC2 PIAS2 PPP1CA PPP1CC RING1 RNF2 RNF4 SCMH1 SDCBP2 SFMBT1 SFMBT2 SIAH1 SP100 SUMO1 SUMO1P1 TET2 UBE2I ZCCHC7	34 interacting genes: ARNT AURKA CASP3 CCDC146 CDKN1A CDKN2A CDT1 CSNK2A1 FZR1 GLIS2 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KANK2 KAT7 LNX1 MCM6 NCF1 PHC1 PTPN11 REPIN1 SAPCD2 SCMH1 SIX3 SMARCA4 UBE2C UBE2S ZNF250 ZNF439
Entrez ID		1911	51053
HPRD ID		16009	06783
Ensembl ID		ENSG00000111752	ENSG00000112312
Uniprot IDs		P78364 Q6GMQ3 Q6N083	A0A024QZY7 O75496
PDB IDs		2L8E	1T6F 1UII 2LP0 2WVR 4BRY
Enriched GO Terms of Interacting Partners?
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