DTNA and KCNJ12

Data Source:
HPRD (in vitro, in vivo)

		DTNA	KCNJ12
Description		dystrobrevin alpha	potassium inwardly rectifying channel subfamily J member 12
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Cell Junction Protein-containing Complex Intermediate Filament Cytoskeleton Synapse	Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Membrane
	Molecular Function	Protein Binding Zinc Ion Binding	Inward Rectifier Potassium Channel Activity Protein Binding
	Biological Process	Striated Muscle Contraction Signal Transduction Chemical Synaptic Transmission Neuromuscular Synaptic Transmission Synaptic Signaling	Potassium Ion Transport Muscle Contraction Regulation Of Heart Contraction Regulation Of Ion Transmembrane Transport Protein Homotetramerization Cardiac Conduction Potassium Ion Import Across Plasma Membrane
Pathways			Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs			Dofetilide Ranolazine Miconazole Yohimbine Dronedarone Butamben
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) PR interval ( 32439900) Urate levels in overweight individuals ( 25811787)	Adult body size ( 32376654) Body mass index ( 28892062 25673413) Height ( 20881960 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist-hip ratio ( 25673412)
Interacting Genes		17 interacting genes: ACTA1 APPL1 DMD DRP2 DTNBP1 GFI1B HMG20A KCNJ12 SNTA1 SNTB1 SNTB2 SNTG1 SNTG2 STAT3 SYNC SYNM UTRN	17 interacting genes: ABLIM1 APBA1 CASK DLG1 DLG2 DLG3 DLG4 DMD DTNA EMD LIN7A LIN7B LIN7C PRKACA SNTA1 SNTB1 SNTB2
Entrez ID		1837	3768
HPRD ID		03141	09083
Ensembl ID		ENSG00000134769	ENSG00000184185
Uniprot IDs		A0A024RC32 B7Z3X3 Q9Y4J8	Q14500
PDB IDs		2E5R
Enriched GO Terms of Interacting Partners?
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