JAG1 and THBS1

Data Source:
HPRD (two hybrid)

		JAG1	THBS1
Description		jagged canonical Notch ligand 1	thrombospondin 1
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Adherens Junction Membrane Apical Plasma Membrane	Extracellular Region Fibrinogen Complex Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen External Side Of Plasma Membrane Cell Surface Sarcoplasmic Reticulum Secretory Granule Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Notch Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Phospholipid Binding Growth Factor Activity	Phosphatidylserine Binding Fibronectin Binding Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Heparin Binding Fibroblast Growth Factor Binding Low-density Lipoprotein Particle Binding Identical Protein Binding Laminin Binding Proteoglycan Binding Transforming Growth Factor Beta Binding Fibrinogen Binding Collagen V Binding
	Biological Process	Angiogenesis Cell Fate Determination Negative Regulation Of Cell-matrix Adhesion Blood Vessel Remodeling Morphogenesis Of An Epithelial Sheet T Cell Mediated Immunity Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Cardiac Right Ventricle Morphogenesis Notch Signaling Pathway Nervous System Development Negative Regulation Of Cell-cell Adhesion Hemopoiesis Keratinocyte Differentiation Negative Regulation Of Cell Migration Response To Muramyl Dipeptide Aorta Morphogenesis Regulation Of Cell Population Proliferation Inner Ear Auditory Receptor Cell Differentiation Myoblast Differentiation Endothelial Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Cardiac Septum Morphogenesis Ciliary Body Morphogenesis Pulmonary Artery Morphogenesis Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Notch Signaling Involved In Heart Development Endocardial Cushion Cell Development Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Nephron Development Glomerular Visceral Epithelial Cell Development Distal Tubule Development Loop Of Henle Development Neuronal Stem Cell Population Maintenance Negative Regulation Of Stem Cell Differentiation	Activation Of MAPK Activity Response To Hypoxia Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Chronic Inflammatory Response Platelet Degranulation Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Inflammatory Response Immune Response Response To Unfolded Protein Cell Cycle Arrest Cell Adhesion Positive Regulation Of Cell Population Proliferation Response To Mechanical Stimulus Response To Glucose Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Plasminogen Activation Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Fibroblast Migration Cell Migration Negative Regulation Of Angiogenesis Peptide Cross-linking Positive Regulation Of Blood Coagulation Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Magnesium Ion Response To Progesterone Negative Regulation Of Interleukin-12 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Transforming Growth Factor Beta1 Production Response To Testosterone Cellular Response To Heat Response To Endoplasmic Reticulum Stress Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Response To Drug Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Engulfment Of Apoptotic Cell Regulation Of Megakaryocyte Differentiation Positive Regulation Of Translation Positive Regulation Of Angiogenesis Behavioral Response To Pain Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Chemotaxis Response To Calcium Ion Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Fibrinolysis Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus RUNX3 regulates NOTCH signaling NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus	Platelet degranulation Signaling by PDGF Integrin cell surface interactions Syndecan interactions Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases		Alagille syndrome Tetralogy of Fallot
GWAS		Birth weight ( 31043758 27680694) Blood pressure ( 21909110) Bone mineral density ( 20096396) Bone mineral density (spine) ( 30172743) Brain morphology (MOSTest) ( 32665545) Cardiac hypertrophy ( 21348951) Cataracts (operation) ( 31816047) Diastolic blood pressure ( 26390057 28135244 27841878 21909115 28739976 27618447 27618452 25249183) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Eosinophil counts ( 32888494) Frontotemporal dementia (age at onset) ( 29724592) Frontotemporal dementia with GRN mutation (age at onset) ( 29724592) Heel bone mineral density ( 30598549 28869591) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Lumbar spine bone mineral density ( 29499414 22504420) Lymphocyte counts ( 32888494) Migraine ( 27322543) Monocyte count ( 32888494) Offspring birth weight ( 31043758) Pulse pressure ( 28135244) Red blood cell count ( 32888494) Systolic blood pressure ( 28135244 27841878 21909115 28739976 27618452 25249183) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Type 2 diabetes ( 28828242) Urate levels ( 31578528) Urinary bladder cancer ( 24861552)	Logical memory (immediate recall) in normal cognition ( 29274321) Urate levels ( 31578528)
Interacting Genes		9 interacting genes: AFDN MFNG MIB1 MTDH NOTCH1 NOTCH2 NOTCH3 POFUT1 THBS1	40 interacting genes: CALCR CALR CD36 CD47 CFH COL1A1 COL2A1 COL3A1 COL4A1 COL5A1 COL7A1 CORO1A CTSG DCN DHFR ELANE F2 FGA FGF2 FN1 HRG IGFBP5 ITGB3 JAG1 KNG1 LAMB3 LRP1 LRP2 LRP5 MMP2 MMP9 MTDH PDGFB PLG SCARB2 SPARC TFPI TGFB1 TNFAIP6 TNFRSF11B
Entrez ID		182	7057
HPRD ID		03562	01765
Ensembl ID		ENSG00000101384	ENSG00000137801
Uniprot IDs		P78504 Q99740	P07996
PDB IDs		2KB9 2VJ2 4CBZ 4CC0 4CC1 4XI7 5BO1	1LSL 1UX6 1Z78 1ZA4 2ERF 2ES3 2OUH 2OUJ 3R6B 5FOE
Enriched GO Terms of Interacting Partners?
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