THBS1 and SCARB2

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		THBS1	SCARB2
Description		thrombospondin 1	scavenger receptor class B member 2
Image
GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen External Side Of Plasma Membrane Cell Surface Sarcoplasmic Reticulum Secretory Granule Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome	Golgi Membrane Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion Endosome Membrane Membrane Integral Component Of Membrane Clathrin-coated Vesicle Membrane Endocytic Vesicle Membrane Late Endosome Membrane Lysosomal Lumen Extracellular Exosome
	Molecular Function	Phosphatidylserine Binding Fibronectin Binding Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Heparin Binding Fibroblast Growth Factor Binding Low-density Lipoprotein Particle Binding Identical Protein Binding Laminin Binding Proteoglycan Binding Transforming Growth Factor Beta Binding Fibrinogen Binding Collagen V Binding	Virus Receptor Activity Phosphatidylserine Binding Transmembrane Signaling Receptor Activity Scavenger Receptor Activity Protein Binding Cholesterol Binding Enzyme Binding Phosphatidylcholine Binding Cargo Receptor Activity Protein Homodimerization Activity
	Biological Process	Activation Of MAPK Activity Response To Hypoxia Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Chronic Inflammatory Response Platelet Degranulation Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Inflammatory Response Immune Response Response To Unfolded Protein Cell Cycle Arrest Cell Adhesion Positive Regulation Of Cell Population Proliferation Response To Mechanical Stimulus Response To Glucose Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Plasminogen Activation Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Fibroblast Migration Cell Migration Negative Regulation Of Angiogenesis Peptide Cross-linking Positive Regulation Of Blood Coagulation Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Magnesium Ion Response To Progesterone Negative Regulation Of Interleukin-12 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Transforming Growth Factor Beta1 Production Response To Testosterone Cellular Response To Heat Response To Endoplasmic Reticulum Stress Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Response To Drug Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Engulfment Of Apoptotic Cell Regulation Of Megakaryocyte Differentiation Positive Regulation Of Translation Positive Regulation Of Angiogenesis Behavioral Response To Pain Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Chemotaxis Response To Calcium Ion Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Fibrinolysis Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Targeting To Lysosome Receptor-mediated Endocytosis Positive Regulation Of Neuron Projection Development Aminophospholipid Transport Regulation Of Cellular Carbohydrate Catabolic Process Viral Entry Into Host Cell Membrane Organization Regulation Of Endosome Organization Regulation Of Glucosylceramidase Activity Regulation Of Lysosome Organization
Pathways		Platelet degranulation Signaling by PDGF Integrin cell surface interactions Syndecan interactions Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases			Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Logical memory (immediate recall) in normal cognition ( 29274321) Urate levels ( 31578528)	BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Estimated glomerular filtration rate ( 31015462) Hippocampal volume ( 29274321) Parkinson's disease ( 25064009 21738487) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		40 interacting genes: CALCR CALR CD36 CD47 CFH COL1A1 COL2A1 COL3A1 COL4A1 COL5A1 COL7A1 CORO1A CTSG DCN DHFR ELANE F2 FGA FGF2 FN1 HRG IGFBP5 ITGB3 JAG1 KNG1 LAMB3 LRP1 LRP2 LRP5 MMP2 MMP9 MTDH PDGFB PLG SCARB2 SPARC TFPI TGFB1 TNFAIP6 TNFRSF11B	10 interacting genes: AP3S1 AP3S2 CLDN19 ERGIC3 GPR37L1 GPX8 HIBADH LAPTM4B LMNA THBS1
Entrez ID		7057	950
HPRD ID		01765	03772
Ensembl ID		ENSG00000137801	ENSG00000138760
Uniprot IDs		P07996	A0A024RDG6 Q14108
PDB IDs		1LSL 1UX6 1Z78 1ZA4 2ERF 2ES3 2OUH 2OUJ 3R6B 5FOE	4F7B 4Q4B 4Q4F 4TVZ 4TW0 4TW2 5UPH 5XBM 6I2K
Enriched GO Terms of Interacting Partners?
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