DR1 and NFYC

Data Source:
BioGRID (two hybrid)

		DR1	NFYC
Description		down-regulator of transcription 1	nuclear transcription factor Y subunit gamma
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GO Annotations	Cellular Component	Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Negative Cofactor 2 Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Core Promoter Sequence-specific DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity TBP-class Protein Binding Protein Heterodimerization Activity	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Histone H3 Acetylation Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Protein Folding Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways		HATs acetylate histones	PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Red blood cell count ( 32888494) Triglyceride levels ( 32203549 29403010) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Urate levels ( 31578528)	Adult body size ( 32376654) Airway obstruction (FEV1/FVC<70%) in never smokers ( 30845926) Airway obstruction (FEV1/FVC<lower limit of normal) in never smokers ( 30845926) Depressive and manic episodes in bipolar disorder ( 26297903) Platelet count ( 21507922) Refractive error ( 32231278)
Interacting Genes		9 interacting genes: DNMT3L DRAP1 NFIL3 NFYC POLE3 TBP XPO1 YEATS2 ZDHHC17	67 interacting genes: ADGRF5 ADNP2 APOL4 ARID2 ATF6 ATF6B BDH2 BICRA BICRAL CEP76 CIART CIC CRX CSN2 CXorf38 DR1 DST ELF1 FAM168A GAPDH HGS HIVEP1 HSFY1 HSFY2 KLF11 KLF15 KLHDC7B LIN54 LMO4 MYC NFYA NFYB NUTM2F OSTF1 PAX4 PAX5 PAX6 POGZ POU3F2 POU6F1 POU6F2 PRR20A PRR20B PRR20C PRR20D PRR20E RAD52 SAE1 SMAD2 SMAD3 SMAP1 SNX2 SP1 SP2 SP4 SREBF2 STOX1 TAF11 TAF12 TAF6 TBP UBXN7 USF3 ZDHHC17 ZMYM6 ZNF34 ZSCAN1
Entrez ID		1810	4802
HPRD ID		03284	05633
Ensembl ID		ENSG00000117505	ENSG00000066136
Uniprot IDs		Q01658 Q658N3	Q13952
PDB IDs		1JFI	1N1J 4AWL 4CSR 6QMP 6QMQ 6QMS
Enriched GO Terms of Interacting Partners?
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