DNTT and PRPF19

Data Source:
HPRD (in vivo, in vitro)

		DNTT	PRPF19
Description		DNA nucleotidylexotransferase	pre-mRNA processing factor 19
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GO Annotations	Cellular Component	Euchromatin Nucleus Nucleoplasm Cytosol Nuclear Matrix	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Lipid Droplet Spindle Membrane Nuclear Speck Site Of Double-strand Break U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity DNA Nucleotidylexotransferase Activity Protein Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin-ubiquitin Ligase Activity Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining DNA Modification Response To ATP DNA Biosynthetic Process	Protein Polyubiquitination Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly Generation Of Catalytic Spliceosome For First Transesterification Step MRNA Splicing, Via Spliceosome Inner Cell Mass Cell Proliferation Transcription-coupled Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Lipid Biosynthetic Process Proteasomal Protein Catabolic Process Cellular Protein Localization Positive Regulation Of Neuron Differentiation Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Astrocyte Differentiation Protein K63-linked Ubiquitination Signal Transduction Involved In DNA Damage Checkpoint
Pathways			Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway
Drugs		2',3'-Dideoxyadenosine triphosphate
Diseases
GWAS
Interacting Genes		9 interacting genes: ABTB2 DNTTIP1 DNTTIP2 MEI4 PCNA PRPF19 REL TCF4 XRCC6	14 interacting genes: DDX42 DNTT EGLN3 ESR1 EXOC7 GSTK1 HSPB1 POLR2A PRPF8 PSMB4 PTEN RPA3 U2AF1 UBE2D3
Entrez ID		1791	27339
HPRD ID		08925	12214
Ensembl ID		ENSG00000107447	ENSG00000110107
Uniprot IDs		P04053	Q9UMS4
PDB IDs		2COE 5W4E	4LG8 5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P
Enriched GO Terms of Interacting Partners?
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