DNMT3A and F8A1

Data Source:
BioGRID (enzymatic study)

		DNMT3A	F8A1
Description		DNA methyltransferase 3 alpha	coagulation factor VIII associated 1
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Euchromatin Heterochromatin XY Body Nucleus Nucleoplasm Cytoplasm Nuclear Matrix	Nucleus Early Endosome Nuclear Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding Transcription Factor Binding DNA-methyltransferase Activity Identical Protein Binding Metal Ion Binding	Molecular_function Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle DNA Methylation DNA Methylation-dependent Heterochromatin Assembly Regulation Of Gene Expression By Genetic Imprinting Spermatogenesis Aging Response To Toxic Substance Response To Ionizing Radiation Response To Lead Ion Positive Regulation Of Cell Death Neuron Differentiation Response To Estradiol Response To Vitamin A Response To Cocaine Response To Drug DNA Methylation Involved In Embryo Development DNA Methylation Involved In Gamete Generation Negative Regulation Of Gene Expression, Epigenetic Cellular Response To Amino Acid Stimulus Cellular Response To Ethanol Cellular Response To Hypoxia C-5 Methylation Of Cytosine Hepatocyte Apoptotic Process	Vesicle Cytoskeletal Trafficking Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways		PRC2 methylates histones and DNA RMTs methylate histone arginines SUMOylation of DNA methylation proteins DNA methylation
Drugs		Procaine Decitabine
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Heel bone mineral density ( 30598549) Height ( 28552196 25282103 25429064 31562340 18391951) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Macular thickness ( 30535121) Monocyte count ( 32888494) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 32888494 27863252) Resistant hypertension ( 31545351) Type 1 diabetes ( 21980299) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		33 interacting genes: CBX1 DDB1 DNMT1 DNMT3B DNMT3L EED EHMT1 EHMT2 EZH2 F8A1 H3C1 H3C6 HDAC1 MDFI MEOX2 MYC NRIP1 PIAS1 PIAS2 PRMT5 PTGES3 SETDB1 SP100 SPI1 SUV39H1 TCL1A TERF2IP UBE2I UHRF1 USP7 ZBTB17 ZBTB18 ZNF513	6 interacting genes: DNMT3A HTT MTNR1A SH3GLB1 SNTA1 TLR10
Entrez ID		1788	8263
HPRD ID		04141	02374
Ensembl ID		ENSG00000119772	ENSG00000277203
Uniprot IDs		A0A0C4DG02 F8WE91 Q59HC6 Q9Y6K1	P23610
PDB IDs		2QRV 3A1A 3A1B 3LLR 3SVM 4QBQ 4QBR 4QBS 4U7P 4U7T 5YX2 6BRR 6F57 6PA7 6W89 6W8B 6W8D 6W8J	6EZ8 6X9O
Enriched GO Terms of Interacting Partners?
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