DYNC1H1 and MRE11

Data Source:
BioGRID (biochemical)

		DYNC1H1	MRE11
Description		dynein cytoplasmic 1 heavy chain 1	MRE11 homolog, double strand break repair nuclease
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GO Annotations	Cellular Component	Extracellular Region Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Cell Cortex Membrane Dynein Complex Azurophil Granule Lumen Extracellular Exosome Axon Cytoplasm	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm Cytosol PML Body Mre11 Complex Site Of Double-strand Break
	Molecular Function	RNA Binding Protein Binding ATP Binding ATP-dependent Microtubule Motor Activity, Minus-end-directed Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding DNA Helicase Activity Double-stranded DNA Binding Nuclease Activity Endodeoxyribonuclease Activity Protein Binding Protein C-terminus Binding 3'-5' Exonuclease Activity 5'-3' Exonuclease Activity Manganese Ion Binding Identical Protein Binding Cadherin Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Microtubule-based Movement Mitotic Spindle Organization Nuclear Migration Retrograde Axonal Transport Regulation Of G2/M Transition Of Mitotic Cell Cycle Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cytoplasmic Microtubule Organization Positive Regulation Of Intracellular Transport P-body Assembly Stress Granule Assembly Neutrophil Degranulation Establishment Of Spindle Localization Cell Division Regulation Of Mitotic Spindle Organization Minus-end-directed Vesicle Transport Along Microtubule Regulation Of Metaphase Plate Congression Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Spindle Assembly	Regulation Of Mitotic Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Replication DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomerase Sister Chromatid Cohesion Mitotic G2 DNA Damage Checkpoint Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Cell Population Proliferation Viral Process Intra-S DNA Damage Checkpoint Telomeric 3' Overhang Formation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Telomere Maintenance Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Positive Regulation Of Kinase Activity Meiotic DNA Double-strand Break Formation Negative Regulation Of Apoptotic Process Mitochondrial Double-strand Break Repair Via Homologous Recombination DNA Strand Resection Involved In Replication Fork Processing Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	Cytosolic sensors of pathogen-associated DNA DNA Damage/Telomere Stress Induced Senescence IRF3-mediated induction of type I IFN HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination
Drugs
Diseases		Distal hereditary motor neuropathies (dHMN)	DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2)
GWAS		Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143)
Interacting Genes		19 interacting genes: BRCA1 COX20 DISC1 DUX4 DYNLL1 EGFR KATNA1 KATNB1 LINC01554 MTNR1B NDEL1 PRKCD RHBDD2 SMAD2 SUMO2 TENT5A TNIK YWHAG YWHAQ	20 interacting genes: ATM ATR CCNE1 CDK2 DCLRE1C DYNLL1 EP300 FANCD2 H2AX LIG1 MAPK8IP2 NBN NEK1 PRKDC RAD50 RECQL5 SPOP SUMO1 SUMO2 XRCC6
Entrez ID		1778	4361
HPRD ID		02524	02889
Ensembl ID		ENSG00000197102	ENSG00000020922
Uniprot IDs		Q14204	A0A024R395 F8W7U8 P49959 Q05D78
PDB IDs		2BOR 2BOT 5NUG 5OWO 6F1T 6F1U 6F1V 6F1Y 6F38 6F3A	3T1I
Enriched GO Terms of Interacting Partners?
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