DLAT and PDK1

Data Source:
BioGRID (proximity labelling technology)
HPRD (in vitro)

		DLAT	PDK1
Description		dihydrolipoamide S-acetyltransferase	pyruvate dehydrogenase kinase 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex Intracellular Membrane-bounded Organelle Pyruvate Dehydrogenase Complex	Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex
	Molecular Function	Dihydrolipoyllysine-residue Acetyltransferase Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity Identical Protein Binding	Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding
	Biological Process	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Tricarboxylic Acid Cycle Protein Phosphopantetheinylation Sleep	Glucose Metabolic Process Protein Phosphorylation Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Glucose Metabolic Process Hypoxia-inducible Factor-1alpha Signaling Pathway
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid
Drugs		NADH Radicicol Dihydrolipoic Acid	4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDE Dichloroacetic acid
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Brain morphology (MOSTest) ( 32665545)	Blood protein levels ( 28240269) Erectile dysfunction in type 1 diabetes ( 22704111) Fasting plasma glucose ( 25187374)
Interacting Genes		7 interacting genes: PDHA1 PDHX PDK1 PDK2 PDK3 PDK4 PRKD3	14 interacting genes: AKT1 DLAT FGFR1 ITGB3 KAT2B LAMTOR5 PDHA1 PDK2 PIK3CA RPS6KB1 SGK1 USP4 XRCC6 YWHAQ
Entrez ID		1737	5163
HPRD ID		10578	03954
Ensembl ID		ENSG00000150768	ENSG00000152256
Uniprot IDs		P10515 Q86YI5	B7Z7N6 Q15118
PDB IDs		1FYC 1Y8N 1Y8O 1Y8P 2DNE 2PNR 2Q8I 3B8K 3CRK 3CRL 6CT0 6H55	2Q8F 2Q8G 2Q8H
Enriched GO Terms of Interacting Partners?
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