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DLAT

Description dihydrolipoamide S-acetyltransferase
Image
GO Annotations Cellular Component
  • Mitochondrion
  • Mitochondrial Matrix
  • Mitochondrial Pyruvate Dehydrogenase Complex
  • Intracellular Membrane-bounded Organelle
  • Pyruvate Dehydrogenase Complex
Molecular Function
  • Dihydrolipoyllysine-residue Acetyltransferase Activity
  • Protein Binding
  • Pyruvate Dehydrogenase (NAD+) Activity
  • Identical Protein Binding
Biological Process
  • Glucose Metabolic Process
  • Acetyl-CoA Biosynthetic Process From Pyruvate
  • Pyruvate Metabolic Process
  • Tricarboxylic Acid Cycle
  • Protein Phosphopantetheinylation
  • Sleep
Pathways
  • Regulation of pyruvate dehydrogenase (PDH) complex
  • Glyoxylate metabolism and glycine degradation
  • Signaling by Retinoic Acid
  • Pyruvate metabolism
Drugs
  • NADH
  • Radicicol
  • Dihydrolipoic Acid
Diseases
  • Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS
  • Brain morphology (MOSTest) ( 32665545)
Interacting Genes 7 interacting genes: PDHA1 PDHX PDK1 PDK2 PDK3 PDK4 PRKD3
Entrez ID 1737
HPRD ID 10578
Ensembl ID ENSG00000150768
Uniprot IDs P10515 Q86YI5
PDB IDs 1FYC 1Y8N 1Y8O 1Y8P 2DNE 2PNR 2Q8I 3B8K 3CRK 3CRL 6CT0 6H55
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025