GLIS3 and ENO1

Data Source:
BioGRID (two hybrid)

		GLIS3	ENO1
Description		GLIS family zinc finger 3	enolase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Phosphopyruvate Hydratase Complex Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Cell Surface Membrane M Band Extracellular Exosome Cell Cortex Region
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding	Magnesium Ion Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific RNA Binding Phosphopyruvate Hydratase Activity Protein Binding Protein Homodimerization Activity Cadherin Binding GTPase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Glycolytic Process Response To Virus Positive Regulation Of Plasminogen Activation Negative Regulation Of Cell Growth Regulation Of Vacuole Fusion, Non-autophagic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Muscle Contraction Canonical Glycolysis Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ATP Biosynthetic Process
Pathways			Glycolysis Gluconeogenesis Manipulation of host energy metabolism
Drugs			Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Permanent neonatal diabetes mellitus (PNDM)
GWAS		Alzheimer's disease biomarkers ( 23562540) Blood sugar levels ( 29403010) Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159 29760442) Cerebrospinal P-tau181p levels ( 28247064) Cerebrospinal T-tau levels ( 28247064) Chin dimples ( 27182965) Chronic obstructive pulmonary disease ( 30804561) Circulating leptin levels or type 2 diabetes ( 32341051) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 25187374) FEV1 ( 30804560) Free thyroxine concentration ( 30367059) Glaucoma (primary angle closure) ( 27064256) Height ( 28552196) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Homeostasis model assessment of beta-cell function ( 20081858) Intraocular pressure ( 29617998 29785010 30054594 30591961 29235454) Low high density lipoprotein cholesterol levels ( 26879886) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Metabolite levels ( 23823483) Methotrexate phramacokinetics (acute lymphoblastic leukemia) ( 19901119) Monocyte count ( 32888494) Neurociticism ( 29500382) Nicotine dependence ( 28440896) Offspring birth weight ( 31043758) Osteoarthritis of the hip or knee ( 29436472) Osteoarthritis of the hip or knee (with total joint replacement) ( 29436472) Peak expiratory flow ( 30804560) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Platelet count ( 32888494) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Spontaneous preterm birth (preterm delivery) ( 25599974) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 30224653) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Type 1 diabetes ( 25751624 19430480 18840781) Type 2 diabetes ( 22885922 24509480 30054458 30297969 26818947 22961080 32499647 22158537 30718926 28869590) White blood cell count ( 32888494)	Asthma ( 30929738) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576) Feeling tense ( 29500382) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Tonsillectomy ( 27182965 28928442) White blood cell count ( 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		11 interacting genes: BAG3 CIB1 CLNK ENO1 ITCH KRTAP6-1 NEK6 SUFU TRAF1 TRIB3 TRIP6	59 interacting genes: AGTPBP1 ALDOA AMBP ARID1B BCL6 BHLHE40 BRCA1 CBX5 CHEK2 CLK1 COL14A1 CYSLTR2 DES DUX4 FANCA FHL1 FLNC FYN GLIS3 GRB2 HDAC1 HEMGN HEY2 HK2 HSP90AB1 HSPA8 HSPB2 ITGB1 IVNS1ABP KDM2A LIG4 LINC01554 LONRF3 MCPH1 MED13 MYOC NCOR1 P4HB PAF1 PCNA PLG PPP2R5E RXFP3 SERPING1 SET SGCG SNAPC3 SRC SUMO2 SUMO4 TCAP TEAD1 TERT TRAPPC2 TTN UPF2 YWHAQ YWHAZ ZBTB44
Entrez ID		169792	2023
HPRD ID		13582	01400
Ensembl ID		ENSG00000107249	ENSG00000074800
Uniprot IDs		A0A0S2Z689 Q1PHJ8 Q8NEA6	A0A024R4F1 P06733
PDB IDs			2PSN 3B97 5JLZ 5LAX 5NI9 5NIG 5OCK
Enriched GO Terms of Interacting Partners?
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