PKD1L1 and PLCB2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vitro)

		PKD1L1	PLCB2
Description		polycystin 1 like 1, transient receptor potential channel interacting	phospholipase C beta 2
Image		No pdb structure
GO Annotations	Cellular Component	Cilium Membrane Calcium Channel Complex Ciliary Membrane Non-motile Cilium	Cytosol
	Molecular Function	Calcium Channel Activity Protein Binding	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding
	Biological Process	Detection Of Nodal Flow Detection Of Mechanical Stimulus Calcium Ion Transmembrane Transport Left/right Axis Specification Cell-cell Adhesion	Phospholipid Metabolic Process G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Wnt Signaling Pathway, Calcium Modulating Pathway Lipid Catabolic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Sensory Perception Of Bitter Taste
Pathways			PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors
Drugs
Diseases
GWAS		Anxiety disorder ( 25390645) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Gut microbiota alpha diversity (Shannon index) ( 33208821) Hepatitis C induced liver fibrosis ( 22841784) Obstructive sleep apnea during REM sleep (apnea hypopnea index) ( 29077507) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566) Neutrophil count ( 32888494) Schizophrenia ( 25056061 29483656) White blood cell count ( 32888494)
Interacting Genes		1 interacting genes: CLK1	7 interacting genes: GNAQ MAP2K3 MAP2K6 SLC9A3R1 SNCA TRPC3 TRPM7
Entrez ID		168507	5330
HPRD ID		10154	04985
Ensembl ID		ENSG00000158683	ENSG00000137841
Uniprot IDs		Q8TDX9	Q00722 Q59F77 Q9BVT6
PDB IDs			2FJU 2ZKM
Enriched GO Terms of Interacting Partners?
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