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DES and PIH1D2
Data Source:
BioGRID
(two hybrid)
DES
PIH1D2
Description
desmin
PIH1 domain containing 2
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytosol
Intermediate Filament
Fascia Adherens
Intercalated Disc
Z Disc
Neuromuscular Junction
Sarcolemma
Intermediate Filament Cytoskeleton
Extracellular Exosome
Cardiac Myofibril
Cytoplasm
R2TP Complex
Ribonucleoprotein Complex
Molecular Function
Structural Constituent Of Cytoskeleton
Protein Binding
Cytoskeletal Protein Binding
Identical Protein Binding
Protein Binding
Small GTPase Binding
Biological Process
Muscle Contraction
Cytoskeleton Organization
Regulation Of Heart Contraction
Muscle Filament Sliding
Intermediate Filament Organization
Box C/D SnoRNP Assembly
RRNA Processing
Pathways
Striated Muscle Contraction
Drugs
Diseases
Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy
Scapuloperoneal myopathy (SPM)
Dilated cardiomyopathy (DCM)
GWAS
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Resting heart rate (
27798624
)
Brain morphology (MOSTest) (
32665545
)
Interacting Genes
60 interacting genes:
AURKB
BAG5
BRCA1
C1orf216
CAPN1
CLIP4
CRYAB
CT55
CWF19L2
DDX6
DSP
DUX1
DUX4
EHHADH
ENO1
GFAP
GOLGA6L9
HSPB1
ITSN1
KRT13
KRT15
KRT20
KRT33B
KRT37
KRT75
LBX1
LENG1
LMO4
LONRF3
M1AP
MAPKAPK2
NEB
NEFL
NEK6
PIAS2
PIH1D2
PKD1
PLEKHA5
POLR2G
PPL
PPP1R18
PRPH
RNF4
ROCK1
S100A1
S100B
SHBG
SNAPIN
SPTAN1
SYNC
SYNM
TCEA2
TFIP11
TRIM55
TRIM63
TRIM7
UBE2I
VIM
YES1
ZMYM5
69 interacting genes:
ANKRD11
BAG3
BANP
CBLL2
CBX8
CCNL2
CDC23
CDCA8
CDKL3
CFAP206
COMMD3
CT55
CTAG1A
CTAG1B
DES
DPH3
DSCAM
EIF4A2
EXOSC5
FRS3
GFAP
GMCL1
GPRASP2
HES7
HSF4
IGF2BP3
IQUB
ITGB3BP
KRTAP12-2
KRTAP12-4
LAP3
LMNB1
MCCD1
MDFI
MED20
MISP
MRFAP1L1
MVP
NFIL3
NHSL2
NOTO
NTAQ1
NXF1
PBX4
PLEKHJ1
POLR1C
PRDM6
PRMT3
RALA
REL
RSPO4
SDCBP
SERTAD1
SLPI
SPRED1
SSX3
SUOX
TAF6
TASOR2
TBATA
TCEA2
TNNI1
TTC23
ZBTB1
ZMAT5
ZNF185
ZNF417
ZNF438
ZNF688
Entrez ID
1674
120379
HPRD ID
00514
14021
Ensembl ID
ENSG00000175084
ENSG00000150773
Uniprot IDs
P17661
Q53SB5
Q8WWB5
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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