DENND1B and GLRX2

Data Source:
BioGRID (affinity chromatography technology)

		DENND1B	GLRX2
Description		DENN domain containing 1B	glutaredoxin 2
Image
GO Annotations	Cellular Component	Cytosol Nuclear Speck Clathrin-coated Vesicle Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Dendrite Neuronal Cell Body Intracellular Membrane-bounded Organelle
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Small GTPase Binding Phosphatidylinositol Phosphate Binding	Protein Disulfide Isomerase Activity Protein Binding Arsenate Reductase (glutaredoxin) Activity Electron Transfer Activity Protein Disulfide Oxidoreductase Activity Glutathione Disulfide Oxidoreductase Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Endocytosis Protein Transport Endocytic Recycling T-helper 2 Cell Cytokine Production Positive Regulation Of GTPase Activity Regulation Of Immune Response T Cell Receptor Signaling Pathway	Regulation Of Transcription, DNA-templated Glutathione Metabolic Process Apoptotic Process Aging Response To Temperature Stimulus Regulation Of Signal Transduction Response To Organic Substance Protein Phosphopantetheinylation Electron Transport Chain Cell Differentiation DNA Protection Response To Hydrogen Peroxide Cell Redox Homeostasis Response To Redox State Cellular Response To Superoxide
Pathways		RAB GEFs exchange GTP for GDP on RABs
Drugs			Glutathione
Diseases
GWAS		Asthma ( 20032318) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coffee consumption (cups per day) ( 31837886) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Depression ( 29700475) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 27479909) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Primary biliary cholangitis ( 21399635 26394269) Primary biliary cirrhosis ( 22961000) Serum protein levels (sST2) ( 23999434) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensities ( 32358547)	Blood protein levels ( 29875488)
Interacting Genes		1 interacting genes: LNX1	4 interacting genes: DCXR ELF5 FBXO7 TXNRD1
Entrez ID		163486	51022
HPRD ID		13303	12112
Ensembl ID		ENSG00000213047	ENSG00000023572
Uniprot IDs		A0A024R987 Q6P3S1	Q9NS18
PDB IDs		3TW8	2CQ9 2FLS 2HT9
Enriched GO Terms of Interacting Partners?
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