RETREG3 and SPPL2C

Data Source:
BioGRID (affinity chromatography technology)

		RETREG3	SPPL2C
Description		reticulophagy regulator family member 3	signal peptide peptidase like 2C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane Protein-containing Complex	Lysosomal Membrane Endoplasmic Reticulum Membrane Golgi-associated Vesicle Membrane Integral Component Of Cytoplasmic Side Of Endoplasmic Reticulum Membrane Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding	Protein Binding Aspartic Endopeptidase Activity, Intramembrane Cleaving Protein Homodimerization Activity
	Biological Process	Positive Regulation Of Neuron Projection Development Reticulophagy	Membrane Protein Ectodomain Proteolysis Membrane Protein Intracellular Domain Proteolysis Membrane Protein Proteolysis
Pathways
Drugs
Diseases
GWAS		Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Alcohol use disorder (total score) ( 30336701) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease ( 30804561) Hand grip strength ( 29691431) Hemoglobin levels ( 32327693) Idiopathic pulmonary fibrosis ( 24429156) Male-pattern baldness ( 28196072) Neuroticism ( 29255261) Parkinson's disease ( 28892059) Red blood cell count ( 27863252)
Interacting Genes		109 interacting genes: ABHD16A ACSL5 AGPAT4 AGTRAP ANKRD46 ARL6IP1 ARPC3 ATP6V0C BET1 BNIP1 C16orf92 C1GALT1 C4orf3 CCDC167 CCL4L2 CDIPT CDS1 CLCA4 CMTM3 CMTM5 CMTM7 CSGALNACT2 CYB5B CYP4F2 DERL1 DHRSX ERG28 FAXDC2 FKBP8 FUNDC2 GABARAPL1 GABARAPL2 GIMAP5 GOSR2 HMOX2 HTATIP2 IFITM3 JAGN1 LEMD1 LPAR3 LPCAT2 LRCH4 MAL2 MALL MAP1LC3A MCRS1 MFF MOB2 MOSPD3 NRM ORMDL2 ORMDL3 OTULINL PKMYT1 PLP2 PLPP6 PNLIPRP1 PRAF2 RABAC1 REEP6 RUSF1 SCD SEC22A SENP2 SERP2 SFT2D1 SFXN3 SLC30A3 SLC39A6 SMCO4 SMIM1 STAP1 STX5 STX7 STX8 SYNGR1 TBRG4 TCEA2 TECR TMEM100 TMEM11 TMEM120B TMEM128 TMEM176A TMEM18 TMEM203 TMEM218 TMEM222 TMEM237 TMEM239 TMEM243 TMEM254 TMEM31 TMEM42 TMEM60 TMEM65 TMPPE TPRG1 TSNARE1 TSPO2 UBIAD1 VAMP1 VAMP3 VAMP4 VAMP5 VAPA VAPB YIPF1 YIPF6	3 interacting genes: CYSRT1 NBPF19 NOTCH2NLA
Entrez ID		162427	162540
HPRD ID		14108	07085
Ensembl ID		ENSG00000141699	ENSG00000185294
Uniprot IDs		K7EQI9 Q86VR2	Q8IUH8
PDB IDs
Enriched GO Terms of Interacting Partners?
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